2. Gene
  3. Itgav - integrin alpha V Gene

Itgav - integrin alpha V Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CD51; 1110004F14Rik; 2610028E01Rik; D430040G12Rik

基因 ID: 16410 | 基因类型: protein coding

关于 Itgav

功能概要

This gene encodes a protein that is a member of the Integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 1, beta 3, beta 6 and beta 8. The heterodimer of alpha v and beta 3 forms the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. In mouse, deficiency of this gene is associated with defects in vascular morphogenesis in the brain and early post-natal death. [provided by RefSeq, May 2013]

Itgav 基因产物(2)

mRNA Protein Name
NM_001398691.1 NP_001385620.1 integrin alpha-V isoform 2 precursor
NM_008402.4 NP_032428.2 integrin alpha-V isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables integrin binding IPI
IPI: 通过物理相互作用推断
20826760 MGI
contributes to opsonin binding IDA
IDA: 通过直接分析推断
20826760 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
38016540 MGI
contributes to protein kinase C binding IDA
IDA: 通过直接分析推断
16014375 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
16014375 MGI
involved in apoptotic cell clearance IDA
IDA: 通过直接分析推断
20826760 MGI
involved in apoptotic cell clearance IGI
IGI: 通过遗传相互作用推断
20826760 MGI
acts upstream of or within apoptotic cell clearance IMP
IMP: 通过突变表型推断
15647754 MGI
acts upstream of or within blood vessel development IMP
IMP: 通过突变表型推断
12370313 MGI
involved in cell adhesion mediated by integrin IDA
IDA: 通过直接分析推断
24681597 MGI
involved in extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: 通过直接分析推断
15591537 MGI
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
20675382 MGI
involved in positive regulation of osteoblast proliferation IMP
IMP: 通过突变表型推断
20675382 MGI
involved in transforming growth factor beta production IDA
IDA: 通过直接分析推断
24681597 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
8557754 MGI
part of integrin alphav-beta5 complex IDA
IDA: 通过直接分析推断
20826760 MGI
part of integrin alphav-beta6 complex IDA
IDA: 通过直接分析推断
24681597 MGI
located in membrane IDA
IDA: 通过直接分析推断
20151413 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
14566019 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

integrin alpha-V

alpha v integrin

vitronectin receptor alpha polypeptide (VNRA)

vitronectin receptor subunit alpha

重组 Itgav 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77723 Integrin alpha V beta 6 Protein, Mouse (HEK293, His) P43406 (F31-V988)&Q9Z0T9 (G22-N706) ≥95%

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P990667 STX-100 Inhibitor 99.99% Phase 2
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06961 ITGAV Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16754 Itgav Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23193 Itgav Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990667B STX-100 (Biotinylated) Inhibitor ≥99.0% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Itgav NCBI NCBI:3685
Macaca fascicularis Itgav NCBI NCBI:102116249
Macaca mulatta Itgav NCBI NCBI:707756
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