Integrin alpha V beta 6 蛋白, Mouse (HEK293, His)

Integrin alpha V beta 3 (ITGAV:ITGB3) functions as a receptor for CD40LG, enhancing Lilrb4a inhibitory effects on mast cell activation. It suppresses marginal zone B cell antibody production through Lilrb4a interaction. ITGAV:ITGB3, forming a heterodimer with ITGAV, interacts with ligands such as RAB25, CIB1, FBLN5, and more. It also forms a complex with PTPRZ1 and PTN, stimulating endothelial cell migration. Integrin alpha V beta 6 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 6 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha V beta 6 Protein, Mouse (HEK293, His), has molecular weight of 90-140 kDa.

ITGAV:ITGB3 可作为 CD40LG 的受体并与 Lilrb4a/Gp49b 受体结合，增强其对肥大细胞活化的抑制作用。ITGAV:ITGB3 还通过与 Lilrb4a 相互作用抑制边缘区 B 细胞抗体的产生。它与 ITGAV 形成异二聚体，并与各种配体相互作用，包括 RAB25、CIB1、FBLN5、CCN3、ADGRA2、FGF2、CX3CR1、CX3CL1、NRG1、ERBB3、FGF1、FGFR1、IGF1、IGF1R、IGF2 和 PTN。它还与 PTPRZ1 和 PTN 形成复合物，刺激内皮细胞迁移。

1. Immobilized Mouse ITGAV&ITGB6, His Tag at 1 μg/mL (100 μl/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC₅₀ of ≤53.2 ng/mL determined by ELISA.
2. Immobilized Mouse ITGAV&ITGB6, His Tag at 2 μg/mL (100 μl/well) on the plate. Dose response curve for Biotinylated Mouse GARP&Latent TGF beta 1 Complex, His Tag with the EC₅₀ of 89.3 ng/mL determined by ELISA.

Mouse

HEK293

C-His

P43406 (F31-V988)&Q9Z0T9 (G22-N706)

16410  [NCBI]&16420  [NCBI]

90-140 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.