2. Gene
  3. Akr1c3 - aldo-keto reductase family 1, member C3 Gene

Akr1c3 - aldo-keto reductase family 1, member C3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Akr1c18

基因 ID: 171516 | 基因类型: protein coding

关于 Akr1c3

功能概要

Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity and alditol:NADP+ 1-oxidoreductase activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to ketone; and female pregnancy. Acts upstream of or within progesterone metabolic process. Located in cytosol and nucleus. Biomarker of polycystic ovary syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to human AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Apr 2022]

Akr1c3 基因产物(1)

mRNA Protein Name
NM_138510.2 NP_612519.1 aldo-keto reductase family 1 member C18
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity IDA
IDA: 通过直接分析推断
4392955 RGD
enables aldo-keto reductase (NADPH) activity IDA
IDA: 通过直接分析推断
8977402 RGD
enables aldose reductase (NADPH) activity IDA
IDA: 通过直接分析推断
8977402 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: 通过表达模式推断
2994767 RGD
involved in cellular response to forskolin IEP
IEP: 通过表达模式推断
9731216 RGD
involved in cellular response to gonadotropin-releasing hormone IEP
IEP: 通过表达模式推断
6778878 RGD
involved in cellular response to prolactin IEP
IEP: 通过表达模式推断
2401226 RGD
involved in cellular response to testosterone stimulus IEP
IEP: 通过表达模式推断
2994767 RGD
involved in cellular response to transforming growth factor beta stimulus IMP
IMP: 通过突变表型推断
2401226 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
9202232 RGD
acts upstream of or within progesterone metabolic process IDA
IDA: 通过直接分析推断
8172618 RGD
involved in progesterone metabolic process IDA
IDA: 通过直接分析推断
4392955 RGD
involved in regulation of steroid biosynthetic process IDA
IDA: 通过直接分析推断
4392955 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
8194472 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

aldo-keto reductase family 1 member C18

20-alpha-HSD

20-alpha-hydroxysteroid dehydrogenase

20alpha-hydroxysteroid dehydrogenase

HSD1

aldo-keto reductase family 1, member C18

aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-19903 ASP-9521 Inhibitor 98.0% Phase 2
Pre-clinical Phase
生物活性分子 (41)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0376 Liquiritin 99.99% 否
HY-150644 S07-2010 Inhibitor 98.35% 否
HY-124573 (R)-Odafosfamide 98.52% 否
HY-138557 AKR1C3-IN-4 Inhibitor 99.77% 否
HY-107379 AKR1C3-IN-1 Inhibitor 98.06% 否
HY-152189 S19-1035 99.77% 否
HY-N10361 Drupanin 99.35% 否
HY-W008567 N-Deschlorobenzoyl indomethacin 95.0% 否
HY-109154 Obafistat Inhibitor 99.92% 否
HY-155035 S07-1066 Inhibitor 99.48% 否
HY-D1342 Coumberol 99.99% 否
HY-152188 AKR1C3-IN-9 Inhibitor 99.77% 否
HY-171115 Pyrone-211 99.32% 否
HY-163940 LX1 Inhibitor 99.13% 否
HY-116170 SN34037 / 否
HY-121656 AKR1C2/3-IN-2 / 否
HY-144749 AKR1C3-IN-5 Inhibitor / 否
HY-146573 AKR1C3-IN-6 Inhibitor / 否
HY-146574 AKR1C3-IN-7 Inhibitor / 否
HY-146575 AKR1C3-IN-8 Inhibitor / 否
HY-149040 Odafosfamide Inhibitor / 否
HY-150646 S07-2009 Inhibitor / 否
HY-150648 S07-2008 Inhibitor / 否
HY-150649 S07-2005 (racemic) Inhibitor / 否
HY-150650 S07-2001 Inhibitor / 否
HY-155502 AKR1C3-IN-10 Inhibitor / 否
HY-157810 AKR1C3-IN-11 Inhibitor / 否
HY-161839 AKR1C2/3-IN-1 Inhibitor / 否
HY-163323 AKR1C3-IN-12 Inhibitor / 否
HY-163609 PROTAC AKR1C3 degrader-1 Degrader / 否
HY-163610 AKR1C3-IN-13 Inhibitor / 否
HY-163784 AKR1C3-IN-14 Inhibitor / 否
HY-173132 AKR1Cs-IN-1 Inhibitor / 否
HY-173453 AKR1C3-IN-15 / 否
HY-176084 RJG-2051 Inhibitor / 否
HY-N0376R Liquiritin (Standard) / 否
HY-RS00536 AKR1C3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W024692 Indomethacin methylester Inhibitor / 否
HY-W706737 N-Deschlorobenzoyl indomethacin-d3 / 否
HY-163647 Lenalidomide-COCH-PEG2-azido / 否
HY-RS23044 Akr1c3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Akr1c3 NCBI NCBI:8644
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