2. Gene
  3. Mdm4 - transformed mouse 3T3 cell double minute 4 Gene

Mdm4 - transformed mouse 3T3 cell double minute 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Mdmx; 4933417N07Rik

基因 ID: 17248 | 基因类型: protein coding

关于 Mdm4

功能概要

This gene encodes a protein that has been shown to negatively regulate the activity of the tumor suppressor protein p53. Homozygous knockout mice exhibit embryonic lethality as a result of p53-dependent Apoptosis and cell cycle arrest. Amplification of this gene or overexpression of the encoded protein has been linked to a range of human cancers. A pseudogene has been identified on the X chromosome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Mdm4 基因产物(5)

mRNA Protein Name
NM_001302801.1 NP_001289730.1 protein Mdm4 isoform 1
NM_001302802.1 NP_001289731.1 protein Mdm4 isoform 1
NM_001302803.1 NP_001289732.1 protein Mdm4 isoform 2
NM_001302804.1 NP_001289733.1 protein Mdm4 isoform 3
NM_008575.4 NP_032601.2 protein Mdm4 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15916963 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within atrial septum development IGI
IGI: 通过遗传相互作用推断
22821713 MGI
acts upstream of or within atrioventricular valve morphogenesis IGI
IGI: 通过遗传相互作用推断
22821713 MGI
acts upstream of or within endocardial cushion morphogenesis IGI
IGI: 通过遗传相互作用推断
22821713 MGI
acts upstream of or within heart valve development IGI
IGI: 通过遗传相互作用推断
22821713 MGI
involved in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: 通过突变表型推断
12101245 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
14712235 MGI
acts upstream of or within regulation of heart rate IGI
IGI: 通过遗传相互作用推断
22821713 MGI
acts upstream of or within ventricular septum development IGI
IGI: 通过遗传相互作用推断
22821713 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein Mdm4

double minute 4 protein

mdm2-like p53-binding protein

p53-binding protein Mdm4

protein Mdmx

相关产品

Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148409 MMRi62 99.59% 否
HY-10412 CEP-1347 98.50% 否
HY-W097753 4-MDM 99.64% 否
HY-123544 RDR03871 MDM2 Inhibitor / 否
HY-146806 YL93 Inhibitor / 否
HY-151169 MDM2/4-p53-IN-1 MDM2 Inhibitor / 否
HY-151170 MDM2/4-p53-IN-2 / 否
HY-151171 MDM2/4-p53-IN-3 Inhibitor / 否
HY-RS08267 MDM4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16923 Mdm4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23366 Mdm4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mdm4 NCBI NCBI:4194
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