2. Gene
  3. Meis1 - Meis homeobox 1 Gene

Meis1 - Meis homeobox 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Evi8; C530044H18Rik

基因 ID: 17268 | 基因类型: protein coding

关于 Meis1

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in negative regulation of myeloid cell differentiation and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including angiogenesis; hemopoiesis; and lens morphogenesis in camera-type eye. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb bud; and sensory organ. Orthologous to human MEIS1 (Meis homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Meis1 基因产物(2)

mRNA Protein Name
NM_001193271.1 NP_001180200.1 homeobox protein Meis1 isoform B
NM_010789.3 NP_034919.1 homeobox protein Meis1 isoform A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
9343407 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
19799567 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10373562 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
9315626 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
19268698 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9315626 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
15634706 MGI
enables sequence-specific DNA binding IGI
IGI: 通过遗传相互作用推断
17049510 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within angiogenesis IMP
IMP: 通过突变表型推断
14713950 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: 通过突变表型推断
15882575 MGI
acts upstream of or within definitive hemopoiesis IMP
IMP: 通过突变表型推断
15882575 MGI
acts upstream of or within hemopoiesis IMP
IMP: 通过突变表型推断
14713950 MGI
acts upstream of or within lens morphogenesis in camera-type eye IMP
IMP: 通过突变表型推断
14713950 MGI
acts upstream of or within locomotory behavior IMP
IMP: 通过突变表型推断
24642863 MGI
acts upstream of or within megakaryocyte development IMP
IMP: 通过突变表型推断
20203303 MGI
involved in negative regulation of myeloid cell differentiation IDA
IDA: 通过直接分析推断
11438208 MGI
acts upstream of or within negative regulation of neuron differentiation IGI
IGI: 通过遗传相互作用推断
18164701 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19799567 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12183364 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
9315626 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
9343407 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

homeobox protein Meis1

myeloid ecotropic viral integration site 1

相关产品

Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15222 Menin-MLL inhibitor MI-2 99.81% 否
HY-134258 MEISi-1 Inhibitor 98.76% 否
HY-134259 MEISi-2 Inhibitor 98.97% 否
HY-132870 MEIS-IN-2 Inhibitor 99.33% 否
HY-RS08325 MEIS1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-122698 CCI-007 Activator 98.45% 否
HY-15222A Menin-MLL inhibitor MI-2 dihydrochloride / 否
HY-155526 FY-21 Inhibitor / 否
HY-160018 BAY-155 Inhibitor / 否
HY-RS08319 MEI1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19217 Meis1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21374 Mei1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25706 Meis1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27893 Mei1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Meis1 NCBI NCBI:4211
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