2. Gene
  3. Nfatc1 - nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 Gene

Nfatc1 - nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: NFAT2; NFATc; NF-ATc; Nfatcb; 2210017P03Rik

基因 ID: 18018 | 基因类型: protein coding

关于 Nfatc1

功能概要

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and mitogen-activated protein kinase p38 binding activity. Involved in heart development and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; branching involved in lymph vessel morphogenesis; and regulation of gene expression. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; eye; genitourinary system; and heart. Orthologous to human NFATC1 (nuclear factor of activated T cells 1). [provided by Alliance of Genome Resources, Apr 2022]

Nfatc1 基因产物(6)

mRNA Protein Name
NM_001164109.1 NP_001157581.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform 3
NM_001164110.1 NP_001157582.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform 4
NM_001164111.1 NP_001157583.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform 6
NM_001164112.1 NP_001157584.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform 5
NM_016791.4 NP_058071.2 nuclear factor of activated T-cells, cytoplasmic 1 isoform 1
NM_198429.2 NP_940821.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
23980096 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
15304486 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
15304486 MGI
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
11889139 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
18408153 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
15304486 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
15304486 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
24301466 MGI
enables mitogen-activated protein kinase p38 binding IPI
IPI: 通过物理相互作用推断
15304486 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15380363 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
7650004 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within B-1a B cell differentiation IMP
IMP: 通过突变表型推断
14595020 MGI
acts upstream of or within G1/S transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
12660151 MGI
involved in aortic valve development IMP
IMP: 通过突变表型推断
22300732 MGI
acts upstream of or within aortic valve morphogenesis IMP
IMP: 通过突变表型推断
9515964 MGI
acts upstream of or within branching involved in lymph vessel morphogenesis IMP
IMP: 通过突变表型推断
19233265 MGI
acts upstream of or within calcineurin-NFAT signaling cascade IMP
IMP: 通过突变表型推断
19233265 MGI
acts upstream of or within calcium ion transport IMP
IMP: 通过突变表型推断
12660151 MGI
acts upstream of or within cell quiescence IMP
IMP: 通过突变表型推断
18243104 MGI
acts upstream of or within cellular response to calcium ion IDA
IDA: 通过直接分析推断
23259949 MGI
involved in endocardial cushion development IGI
IGI: 通过遗传相互作用推断
22300732 MGI
acts upstream of or within epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
15339668 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
23259949 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
15339668 MGI
acts upstream of or within heart trabecula morphogenesis IMP
IMP: 通过突变表型推断
9515963 MGI
involved in heart valve development IMP
IMP: 通过突变表型推断
22300732 MGI
acts upstream of or within heart valve morphogenesis IMP
IMP: 通过突变表型推断
9515963 MGI
acts upstream of keratinocyte proliferation IMP
IMP: 通过突变表型推断
18243104 MGI
acts upstream of or within lymphangiogenesis IGI
IGI: 通过遗传相互作用推断
19233265 MGI
acts upstream of or within negative regulation of keratinocyte proliferation IMP
IMP: 通过突变表型推断
18243104 MGI
acts upstream of or within negative regulation of osteoblast differentiation IDA
IDA: 通过直接分析推断
19463978 MGI
acts upstream of or within negative regulation of stem cell proliferation IMP
IMP: 通过突变表型推断
18243104 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19463978 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
19463978 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18243104 MGI
acts upstream of or within osteoclast differentiation IGI
IGI: 通过遗传相互作用推断
21982707 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: 通过直接分析推断
22451653 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12808150 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15304486 MGI
involved in pulmonary valve development IMP
IMP: 通过突变表型推断
22300732 MGI
acts upstream of or within pulmonary valve morphogenesis IMP
IMP: 通过突变表型推断
9515964 MGI
acts upstream of or within regulation of hair cycle IMP
IMP: 通过突变表型推断
18243104 MGI
involved in regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22019888 MGI
involved in semi-lunar valve development IMP
IMP: 通过突变表型推断
22300732 MGI
acts upstream of stem cell proliferation IMP
IMP: 通过突变表型推断
18243104 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19233265 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
19463978 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18243104 MGI
acts upstream of or within transition between fast and slow fiber IMP
IMP: 通过突变表型推断
18408153 MGI
acts upstream of or within ventricular septum morphogenesis IMP
IMP: 通过突变表型推断
9515964 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
23259949 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
10903175 MGI
is active in nucleus IDA
IDA: 通过直接分析推断
23259949 MGI
located in nucleus IDA
IDA: 通过直接分析推断
9515963 MGI
part of transcription regulator complex IPI
IPI: 通过物理相互作用推断
19561615 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

nuclear factor of activated T-cells, cytoplasmic 1

NF-ATc1

NFAT transcription complex cytosolic component

transcription factor NF-ATc

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-113756A Latanoprost acid Inhibitor 99.62% 否
Pre-clinical Phase
生物活性分子 (18)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0656 Usnic acid 98.90% 否
HY-N2119 Sciadopitysin Inhibitor ≥99.0% 否
HY-147369 NFATc1-IN-1 Inhibitor 99.97% 否
HY-N0231 Bavachalcone 99.90% 否
HY-15001G Stemregenin 1 (GMP) Antagonist / 否
HY-N2157 Pteryxin Inhibitor 99.96% 否
HY-123503 Salicortin Inhibitor / 否
HY-124958 NDMC101 Inhibitor 99.91% 否
HY-149852 Anti-osteoporosis agent-3 / 否
HY-162280 PROTAC BTK Degrader-9 / 否
HY-N12604 Penicisteck acid F Inhibitor / 否
HY-N2528 Usnic acid sodium Inhibitor / 否
HY-N3071 Picrasidine I / 否
HY-P4684 Osteostatin / 否
HY-RS09238 NFATC1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W641445 ELP-004 Inhibitor / 否
HY-RS18427 Nfatc1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24908 Nfatc1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nfatc1 NCBI NCBI:4772
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