2. Gene
  3. EFNA1 - ephrin A1 Gene

EFNA1 - ephrin A1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肾上腺素 A1

种属: Homo sapiens

同用名: B61; EFL1; GMAN; ECKLG; EPLG1; LERK1; LERK-1; TNFAIP4

基因 ID: 1942 | 基因类型: protein coding

关于 EFNA1

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,127,876-155,134,899 (from NCBI)

This gene has 5 transcripts (splice variants), 277 orthologues and 7 paralogues. Broad expression in placenta (RPKM 65.2), lung (RPKM 54.9) and 22 other tissues.

功能概要

该基因编码肝配蛋白 (EPH) 家族的一个成员。肝配蛋白和 EPH 相关受体包含受体蛋白-酪氨酸激酶的最大亚家族，并且与介导发育事件有关，尤其是在神经系统和红细胞生成中。基于它们的结构和序列关系，肝配蛋白分为肝配蛋白-A (EFNA) 类和肝配蛋白 B (EFNB) 类，前者通过糖基磷脂酰肌醇键固定在膜上，后者是跨膜蛋白。该基因编码与 EPHA2、EPHA4、EPHA5、EPHA6 和 EphA7 受体结合的 EFNA 类肝配蛋白。通过序列分析鉴定了编码不同亚型的两种转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the ephrin (EPH) family. The Ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EphA2, EphA4, EphA5, EphA6, and EphA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

EFNA1 基因产物(2)

mRNA Protein Name
NM_004428.3 NP_004419.2 ephrin-A1 isoform a precursor
NM_182685.2 NP_872626.1 ephrin-A1 isoform b precursor

EFNA1 蛋白结构

Ephrin

Ephrin: Ephrin (16 - 152)

  • 0
  • 100
  • 205 a.a.
蛋白主名 其他名称

ephrin-A1

TNF alpha-induced protein 4

重组 EFNA1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70164 Ephrin-A1/EFNA1 Protein, Human (AAH32698.1, HEK293, His) AAH32698.1/NP_004419.2 (D19-S182) ≥95%
HY-P72006 Ephrin-A1/EFNA1 Protein, Human (HEK 293, hFc) P20827 (D19-S182) ≥95%
HY-P72662 Ephrin-A1/EFNA1 Protein, Human (HEK293, Fc) P20827 (D19-S182) ≥95%
HY-P73519 Ephrin-A1/EFNA1 Protein, Human (182a.a, HEK293, His) P20827 (M1-S182) ≥95%
HY-P73023 Ephrin-A1/EFNA1 Protein, Human (HEK293, His-Fc) P20827 (M1-S182) ≥95%
HY-P70164A Ephrin-A1/EFNA1 Protein, Human (164a.a, HEK293, C-His) AAH32698.1(D19-S182) ≥95%

关联疾病

疾病名称 别名
Cortical Senile Cataract
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04192 EFNA1 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta EFNA1 VGNC VGNC:72167
Canis familiaris EFNA1 VGNC VGNC:40226
Felis catus EFNA1 VGNC VGNC:61748
Bos taurus EFNA1 VGNC VGNC:28355
Rattus norvegicus EFNA1 RGD RGD:620388
Mus musculus EFNA1 MGD MGI:103236
Others EFNA1 NCBI
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