SDR16C5 - short chain dehydrogenase/reductase family 16C member 5 Gene

中文名称：短链脱氢酶/还原酶家族 16C 成员 5

种属: Homo sapiens

同用名: RDH#2; RDHE2; EPHD-2; RDH-E2; retSDR2

关于 SDR16C5

功能概要

该基因编码蛋白质的短链醇脱氢酶/还原酶超家族的成员，并参与视黄醇向视黄醛的氧化。编码的蛋白质与内质网相关，预计包含三个跨膜螺旋，表明它是一种完整的膜蛋白。它识别全反式视黄醇和全反式视黄醛作为底物，并表现出对 NAD (+) /NADH 作为辅助因子的强烈偏好。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 12 月]

This gene encodes a member of the short-chain alcohol dehydrogenase/reductase superfamily of proteins and is involved in the oxidation of retinol to retinaldehyde. The encoded protein is associated with the endoplasmic reticulum and is predicted to contain three transmembrane helices, suggesting that it is an integral membrane protein. It recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]