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  2. RDM1 - RAD52 motif containing 1 Gene

RDM1 - RAD52 motif containing 1 Gene

中文名称:含 RAD52 基序 1

种属: Homo sapiens

同用名: RAD52B

基因 ID: 201299 | 基因类型: protein coding

关于 RDM1

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,918,080-35,930,773 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele and 193 orthologues. Biased expression in testis (RPKM 2.2), lymph node (RPKM 0.3) and 5 other tissues.

功能概要

该基因编码一种蛋白质,该蛋白质参与细胞对顺铂 (一种常用于化疗的药物) 的反应。该基因编码的蛋白质包含两个基序:一个在 RAD52 中发现的基序,一种在 DNA 双链断裂和同源重组中起作用的蛋白质,以及一个在 RAD52 中未发现的 RNA 识别基序 (RRM) 。 RAD52 中的 RAD52 基序区域对蛋白质功能很重要,可能参与 DNA 结合或寡聚化。已经报道了编码不同亚型的可变剪接转录物变体。[RefSeq 提供,2008 年 7 月]

This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. [provided by RefSeq, Jul 2008]

RDM1 基因产物(9)

mRNA Protein Name
NM_001034836.2 NP_001030008.1 RAD52 motif-containing protein 1 isoform 2
NM_001163120.2 NP_001156592.1 RAD52 motif-containing protein 1 isoform 3
NM_001163121.2 NP_001156593.1 RAD52 motif-containing protein 1 isoform 4
NM_001163122.1 NP_001156594.1 RAD52 motif-containing protein 1 isoform 5
NM_001163124.1 NP_001156596.1 RAD52 motif-containing protein 1 isoform 6
NM_001163125.1 NP_001156597.1 RAD52 motif-containing protein 1 isoform 7
NM_001163130.1 NP_001156602.1 RAD52 motif-containing protein 1 isoform 8
NM_001330194.2 NP_001317123.1 RAD52 motif-containing protein 1 isoform 9
NM_145654.4 NP_663629.1 RAD52 motif-containing protein 1 isoform 1

RDM1 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (32 - 88)

Rad52_Rad22

Rad52_Rad22: Rad52/22 family double-strand break repair protein (92 - 210)

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  • 284 a.a.
蛋白主名 其他名称

RAD52 motif-containing protein 1

RAD52 homolog B

关联疾病

疾病名称 别名
Plummer'S Disease

Toxic Nodular Goiter

Plummer Disease

Goiter Toxic Nodular

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RDM1 RGD RGD:1310432
Macaca mulatta RDM1 VGNC VGNC:76778
Bos taurus RDM1 VGNC VGNC:33844
Mus musculus RDM1 MGD MGI:1913849