2. Gene
  3. Six2 - sine oculis-related homeobox 2 Gene

Six2 - sine oculis-related homeobox 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 20472 | 基因类型: protein coding

关于 Six2

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic morphogenesis; kidney development; and positive regulation of chondrocyte proliferation. Acts upstream of or within several processes, including animal organ development; condensed mesenchymal cell proliferation; and protein import into nucleus. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human SIX2 (SIX homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Six2 基因产物(1)

mRNA Protein Name
NM_011380.2 NP_035510.1 homeobox protein SIX2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
15327782 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
15327782 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
15327782 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11734542 MGI
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
17785448 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8814301 MGI
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
22902740 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in anterior/posterior axis specification IDA
IDA: 通过直接分析推断
18321982 MGI
acts upstream of or within cell population proliferation IMP
IMP: 通过突变表型推断
20515681 MGI
acts upstream of or within chondrocyte differentiation IMP
IMP: 通过突变表型推断
20515681 MGI
acts upstream of or within condensed mesenchymal cell proliferation IGI
IGI: 通过遗传相互作用推断
26116661 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: 通过突变表型推断
20515681 MGI
involved in embryonic digestive tract morphogenesis IMP
IMP: 通过突变表型推断
19660448 MGI
acts upstream of or within embryonic skeletal system morphogenesis IGI
IGI: 通过遗传相互作用推断
15634706 MGI
acts upstream of epithelial cell differentiation IMP
IMP: 通过突变表型推断
17036046 MGI
involved in kidney development IMP
IMP: 通过突变表型推断
17036046 MGI
involved in mesenchymal cell differentiation involved in kidney development IMP
IMP: 通过突变表型推断
17036046 MGI
involved in mesenchymal stem cell maintenance involved in nephron morphogenesis IDA
IDA: 通过直接分析推断
22902740 MGI
involved in mesenchymal stem cell maintenance involved in nephron morphogenesis IMP
IMP: 通过突变表型推断
18682239 MGI
involved in mesenchymal stem cell proliferation IMP
IMP: 通过突变表型推断
21350016 MGI
involved in mesenchymal to epithelial transition involved in metanephros morphogenesis IEP
IEP: 通过表达模式推断
10322633 MGI
involved in mesodermal cell fate specification IDA
IDA: 通过直接分析推断
17785448 MGI
acts upstream of or within metanephros development IMP
IMP: 通过突变表型推断
17036046 MGI
acts upstream of or within middle ear morphogenesis IGI
IGI: 通过遗传相互作用推断
15634706 MGI
acts upstream of or within negative regulation of epithelial cell differentiation IMP
IMP: 通过突变表型推断
17036046 MGI
involved in nephron development IMP
IMP: 通过突变表型推断
18682239 MGI
involved in nephron morphogenesis IMP
IMP: 通过突变表型推断
17036046 MGI
involved in positive regulation of chondrocyte proliferation IMP
IMP: 通过突变表型推断
20515681 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15327782 MGI
acts upstream of or within protein import into nucleus IDA
IDA: 通过直接分析推断
16024294 MGI
involved in regulation of branching involved in ureteric bud morphogenesis IMP
IMP: 通过突变表型推断
17036046 MGI
involved in regulation of chondrocyte differentiation IMP
IMP: 通过突变表型推断
20515681 MGI
involved in regulation of ossification IMP
IMP: 通过突变表型推断
20515681 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
8814301 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

homeobox protein SIX2

sine oculis homeobox homolog 2

sine oculis-related homeobox 2 homolog

Six2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Six2 Q62232 Eya1 Mus musculus P97767
Pull Down
11734542
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12959 SIX2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19955 Six2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26457 Six2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Six2 NCBI NCBI:10736
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