2. Gene
  3. Cblb - Casitas B-lineage lymphoma b Gene

Cblb - Casitas B-lineage lymphoma b Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Cbl-b

基因 ID: 208650 | 基因类型: protein coding

关于 Cblb

功能概要

Predicted to enable SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein Ligase activity. Involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway. Acts upstream of or within several processes, including T cell receptor signaling pathway; positive regulation of T cell anergy; and positive regulation of protein metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in membrane raft and plasma membrane. Is expressed in brain; extrinsic ocular muscle; and incisor. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B). [provided by Alliance of Genome Resources, Apr 2022]

Cblb 基因产物(1)

mRNA Protein Name
NM_001033238.1 NP_001028410.1 E3 ubiquitin-protein ligase CBL-B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12697763 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of CD4-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
14973438 MGI
acts upstream of or within T cell activation IMP
IMP: 通过突变表型推断
11070165 MGI
acts upstream of T cell anergy IMP
IMP: 通过突变表型推断
14973438 MGI
acts upstream of or within T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
12697763 MGI
acts upstream of or within immune response IMP
IMP: 通过突变表型推断
11070165 MGI
acts upstream of or within intracellular signal transduction IMP
IMP: 通过突变表型推断
11070165 MGI
acts upstream of or within negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
14973438 MGI
acts upstream of or within negative regulation of T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
14738763 MGI
acts upstream of or within peptidyl-amino acid modification IDA
IDA: 通过直接分析推断
12697763 MGI
acts upstream of or within positive regulation of T cell anergy IMP
IMP: 通过突变表型推断
14973438 MGI
acts upstream of or within positive regulation of protein catabolic process IMP
IMP: 通过突变表型推断
14973438 MGI
acts upstream of or within positive regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
12697763 MGI
acts upstream of protein catabolic process IMP
IMP: 通过突变表型推断
14973438 MGI
acts upstream of or within regulation of GTPase activity IMP
IMP: 通过突变表型推断
12697763 MGI
acts upstream of or within regulation of cell adhesion IMP
IMP: 通过突变表型推断
12697763 MGI
involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway IMP
IMP: 通过突变表型推断
29237719 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: 通过直接分析推断
32606037 MGI
acts upstream of or within regulation of protein binding IMP
IMP: 通过突变表型推断
12697763 MGI
involved in regulation protein catabolic process at postsynapse IDA
IDA: 通过直接分析推断
32606037 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
32606037 MGI
is active in postsynapse IDA
IDA: 通过直接分析推断
32606037 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

E3 ubiquitin-protein ligase CBL-B

RING-type E3 ubiquitin transferase CBL-B

SH3-binding protein CBL-B

casitas B-lineage lymphoma proto-oncogene b

signal transduction protein CBL-B

Cblb 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Cblb Q3TTA7 Cd5 Mus musculus P13379
Affinity Chrom
27474268
种属内
Cblb Q3TTA7 Cd5 Mus musculus P13379
Anti Bait CoIP
27474268
种属内
Cblb Q3TTA7 Ticam1 Mus musculus Q80UF7
Anti Tag CoIP
20639876
种属内
Cblb Q3TTA7 Ticam1 Mus musculus Q80UF7
Anti Bait CoIP
20639876
种属内
Cblb Q3TTA7 Myd88 Mus musculus P22366
Anti Bait CoIP
20639876
种属内
Cblb Q3TTA7 Myd88 Mus musculus P22366
Anti Tag CoIP
20639876
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (27)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-141432 NX-1607 Inhibitor 99.87% 否
HY-136339 Cbl-b-IN-1 Inhibitor 99.66% 否
HY-155120 Cbl-b-IN-5 Inhibitor 99.61% 否
HY-141431 Cbl-b-IN-2 Inhibitor / 否
HY-155477 Cbl-b-IN-15 Inhibitor / 否
HY-156766 Cbl-b-IN-10 Inhibitor / 否
HY-156768 Cbl-b-IN-12 Inhibitor / 否
HY-156769 Cbl-b-IN-13 Inhibitor / 否
HY-161977 Cbl-b-IN-26 Inhibitor / 否
HY-156762 Cbl-b-IN-6 Inhibitor / 否
HY-156763 Cbl-b-IN-7 Inhibitor / 否
HY-156764 Cbl-b-IN-8 Inhibitor / 否
HY-156765 Cbl-b-IN-9 Inhibitor / 否
HY-156767 Cbl-b-IN-11 Inhibitor / 否
HY-158171 Cbl-b-IN-17 Inhibitor / 否
HY-158172 Cbl-b-IN-18 Inhibitor / 否
HY-158173 Cbl-b-IN-19 Inhibitor / 否
HY-158174 Cbl-b-IN-20 Inhibitor / 否
HY-159608 PROTAC Cbl-b-IN-1 / 否
HY-163194 Cbl-b-IN-16 Inhibitor / 否
HY-169005 Cbl-b-IN-27 Inhibitor / 否
HY-173311 Cbl-b-IN-28 / 否
HY-RS01997 CBLB Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS08508 MMAB Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-141432G NX-1607 (GMP) Inhibitor / 否
HY-RS17948 Cblb Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24419 Cblb Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cblb NCBI NCBI:868
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