2. Gene
  3. Arrb2 - arrestin, beta 2 Gene

Arrb2 - arrestin, beta 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Arr3

基因 ID: 216869 | 基因类型: protein coding

关于 Arrb2

功能概要

Enables protein kinase B binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of cell communication; and regulation of protein phosphorylation. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway and regulation of protein phosphorylation. Predicted to be located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and postsynaptic density. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human ARRB2 (Arrestin beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Arrb2 基因产物(4)

mRNA Protein Name
NM_001271358.1 NP_001258287.1 beta-arrestin-2 isoform a
NM_001271359.1 NP_001258288.1 beta-arrestin-2 isoform a
NM_001271360.1 NP_001258289.1 beta-arrestin-2 isoform b
NM_145429.5 NP_663404.1 beta-arrestin-2 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18952848 MGI
enables protein kinase B binding IPI
IPI: 通过物理相互作用推断
16051150 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adult walking behavior IMP
IMP: 通过突变表型推断
16051150 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
27886171 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
27886171 MGI
involved in negative regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
16378096 MGI
involved in negative regulation of interleukin-12 production IMP
IMP: 通过突变表型推断
16378096 MGI
involved in negative regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
16378096 MGI
involved in negative regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
24974728 MGI
involved in negative regulation of toll-like receptor signaling pathway IMP
IMP: 通过突变表型推断
16378096 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
16378096 MGI
involved in positive regulation of cardiac muscle cell differentiation IDA
IDA: 通过直接分析推断
24974728 MGI
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
24974728 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
16051150 MGI
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
24974728 MGI
involved in positive regulation of synaptic transmission, dopaminergic IMP
IMP: 通过突变表型推断
16051150 MGI
involved in postsynaptic signal transduction IDA
IDA: 通过直接分析推断
27886171 MGI
involved in postsynaptic signal transduction IMP
IMP: 通过突变表型推断
27886171 MGI
acts upstream of or within regulation of G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
10617462 MGI
acts upstream of or within regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
15218143 MGI
acts upstream of or within regulation of protein phosphorylation IGI
IGI: 通过遗传相互作用推断
15218143 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
27886171 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
27886171 MGI
located in intracellular anatomical structure IDA
IDA: 通过直接分析推断
11171997 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

beta-arrestin-2

arrestin 3

beta arr2

Arrb2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Arrb2 Q91YI4 Ffar4 Mus musculus Q7TMA4
Confocal
20813258
种属内
Arrb2 Q91YI4 Card10 Mus musculus P58660
Anti Tag CoIP
18952848
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01029 ARRB2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20857 Arrb2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27372 Arrb2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Arrb2 NCBI NCBI:409
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