2. Gene
  3. Tyrobp - TYRO protein tyrosine kinase binding protein Gene

Tyrobp - TYRO protein tyrosine kinase binding protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ly83; DAP12; KARAP

基因 ID: 22177 | 基因类型: protein coding

关于 Tyrobp

功能概要

Enables signaling receptor binding activity. Involved in several processes, including myeloid cell activation involved in immune response; regulation of cytokine production; and regulation of lymphocyte activation. Acts upstream of or within osteoclast differentiation and regulation of osteoclast development. Located in cell surface. Is expressed in blood vessel; brain; central nervous system; corpus callosum; and embryo. Used to study Nasu-Hakola disease. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Orthologous to human TYROBP (transmembrane immune signaling adaptor TYROBP). [provided by Alliance of Genome Resources, Apr 2022]

Tyrobp 基因产物(1)

mRNA Protein Name
NM_011662.3 NP_035792.1 TYRO protein tyrosine kinase-binding protein precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9647200 MGI
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
16715077 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
IDA: 通过直接分析推断
16715077 MGI
involved in actin cytoskeleton organization IMP
IMP: 通过突变表型推断
18691974 MGI
involved in apoptotic cell clearance IMP
IMP: 通过突变表型推断
15728241 MGI
involved in forebrain development IDA
IDA: 通过直接分析推断
18685038 MGI
involved in integrin-mediated signaling pathway IMP
IMP: 通过突变表型推断
17086186 MGI
involved in macrophage activation involved in immune response IMP
IMP: 通过突变表型推断
17086186 MGI
involved in microglial cell activation involved in immune response IMP
IMP: 通过突变表型推断
25690660 MGI
involved in negative regulation of B cell proliferation IMP
IMP: 通过突变表型推断
21727189 MGI
involved in negative regulation of interleukin-10 production IMP
IMP: 通过突变表型推断
25690660 MGI
involved in negative regulation of long-term synaptic potentiation IMP
IMP: 通过突变表型推断
15601948 MGI
involved in negative regulation of transforming growth factor beta1 production IMP
IMP: 通过突变表型推断
25690660 MGI
involved in neutrophil activation involved in immune response IMP
IMP: 通过突变表型推断
17086186 MGI
acts upstream of or within osteoclast differentiation IDA
IDA: 通过直接分析推断
21841309 MGI
acts upstream of or within osteoclast differentiation IGI
IGI: 通过遗传相互作用推断
21841309 MGI
acts upstream of or within osteoclast differentiation IMP
IMP: 通过突变表型推断
21841309 MGI
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
25690660 MGI
involved in positive regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
25690660 MGI
involved in positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
25690660 MGI
involved in positive regulation of macrophage fusion IMP
IMP: 通过突变表型推断
18957693 MGI
involved in positive regulation of microglial cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
18685038 MGI
involved in positive regulation of natural killer cell activation IDA
IDA: 通过直接分析推断
9647200 MGI
involved in positive regulation of osteoclast development IMP
IMP: 通过突变表型推断
14969392 MGI
involved in positive regulation of receptor localization to synapse IMP
IMP: 通过突变表型推断
15601948 MGI
involved in positive regulation of superoxide anion generation IDA
IDA: 通过直接分析推断
18685038 MGI
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
25690660 MGI
acts upstream of or within regulation of osteoclast development IGI
IGI: 通过遗传相互作用推断
22451653 MGI
involved in response to axon injury IMP
IMP: 通过突变表型推断
25690660 MGI
involved in semaphorin-plexin signaling pathway IDA
IDA: 通过直接分析推断
16715077 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
9647200 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

TYRO protein tyrosine kinase-binding protein

DNAX-activation protein 12

KAR-associated protein

killer cell activating receptor associated protein

killer-activating receptor-associated protein

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15309 TYROBP Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21215 Tyrobp Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27731 Tyrobp Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tyrobp NCBI NCBI:7305
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z