2. Gene
  3. NAPEPLD - N-acyl phosphatidylethanolamine phospholipase D Gene

NAPEPLD - N-acyl phosphatidylethanolamine phospholipase D Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：N-酰基磷脂酰乙醇胺磷脂酶 D

种属: Homo sapiens

同用名: FMP30; C7orf18; NAPE-PLD

基因 ID: 222236 | 基因类型: protein coding

关于 NAPEPLD

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:103,099,776-103,150,001 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele and 220 orthologues. Ubiquitous expression in brain (RPKM 8.2), kidney (RPKM 8.2) and 25 other tissues.

功能概要

NAPEPLD 是一种磷脂酶 D 型酶，可在 N-酰基乙醇胺生物合成的第二步中催化 N-酰基磷脂酰乙醇胺 (NAPE) 释放 N-酰基乙醇胺 (NAE) (Okamoto 等人，2004 [PubMed 14634025]) .[OMIM 提供，2008 年 10 月]

NAPEPLD is a Phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al., 2004 [PubMed 14634025]).[supplied by OMIM, Oct 2008]

NAPEPLD 基因产物(21)

mRNA Protein Name
NM_001122838.3 NP_001116310.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386176.1 NP_001373105.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386177.1 NP_001373106.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386179.1 NP_001373108.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386182.1 NP_001373111.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386185.1 NP_001373114.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386189.1 NP_001373118.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 4
NM_001386190.1 NP_001373119.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386191.1 NP_001373120.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386193.1 NP_001373122.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386194.1 NP_001373123.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386204.1 NP_001373133.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386205.1 NP_001373134.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 2
NM_001386207.1 NP_001373136.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 2
NM_001386208.1 NP_001373137.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386209.1 NP_001373138.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386210.1 NP_001373139.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 3
NM_001386211.1 NP_001373140.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 2
NM_001386212.1 NP_001373141.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_001386213.1 NP_001373142.1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
NM_198990.6 NP_945341.3 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables N-acylphosphatidylethanolamine-specific phospholipase D activity IDA
IDA: 通过直接分析推断
25684574 GOA
enables bile acid binding IDA
IDA: 通过直接分析推断
27571266 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25684574 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
25684574 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in N-acylphosphatidylethanolamine metabolic process IDA
IDA: 通过直接分析推断
25684574 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
25684574 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NAPEPLD 蛋白结构

Lactamase_B_2

Lactamase_B_2: Beta-lactamase superfamily domain (144 - 344)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
蛋白主名 其他名称

N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D

NAPE-hydrolyzing phospholipase D

NAPEPLD 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NAPEPLD Q6IQ20 NAPEPLD Homo sapiens Q6IQ20
Comig Non-Denat Gel
25684574
种属内
NAPEPLD Q6IQ20 NAPEPLD Homo sapiens Q6IQ20
GMS
25684574
种属内
NAPEPLD Q6IQ20 NAPEPLD Homo sapiens Q6IQ20
X-Ray Diffraction
25684574
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Vulvar Syringoma
Cannabis Abuse

Marijuana Abuse
Cannabis Dependence

Marijuana Abuse

Cannabinoid Addiction

Cannabinoid Dependence

Cannabis Addiction
Hallucinogen Dependence

Hallucinogen Addiction
Lennox-Gastaut Syndrome

Lennox Syndrome

Encephalopathy Of Childhood

Epileptic Encephalopathy Lennox-Gastaut Type

Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves

Lgs
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-131181 LEI-401 Inhibitor 99.73% 否
HY-155774 VU533 99.71% 否
HY-155773 VU534 Inhibitor 98.53% 否
HY-118994 ARN19874 Inhibitor 99.54% 否
HY-RS09031 NAPEPLD Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22012 Napepld Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28530 Napepld Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus NAPEPLD VGNC VGNC:31883
Rattus norvegicus NAPEPLD RGD RGD:735197
Felis catus NAPEPLD VGNC VGNC:63721
Canis familiaris NAPEPLD VGNC VGNC:43621
Mus musculus NAPEPLD MGD MGI:2140885
Macaca mulatta NAPEPLD VGNC VGNC:75001
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