2. Gene
  3. Wnt4 - wingless-type MMTV integration site family, member 4 Gene

Wnt4 - wingless-type MMTV integration site family, member 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Wnt-4

基因 ID: 22417 | 基因类型: protein coding

关于 Wnt4

功能概要

Enables Frizzled binding activity and transcription corepressor activity. Involved in several processes, including paramesonephric duct development; positive regulation of cellular component biogenesis; and regulation of cellular biosynthetic process. Acts upstream of or within several processes, including animal organ development; negative regulation of signal transduction; and renal vesicle induction. Located in cell surface; extracellular matrix; and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism. Orthologous to human WNT4 (Wnt family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Wnt4 基因产物(1)

mRNA Protein Name
NM_009523.2 NP_033549.1 protein Wnt-4 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables frizzled binding IPI
IPI: 通过物理相互作用推断
15265686 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9853965 MGI
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
12949260 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Sertoli cell differentiation IMP
IMP: 通过突变表型推断
15581876 MGI
acts upstream of or within T cell differentiation in thymus IDA
IDA: 通过直接分析推断
11265645 MGI
acts upstream of or within anatomical structure development IGI
IGI: 通过遗传相互作用推断
16818445 MGI
acts upstream of apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
20454446 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IMP
IMP: 通过突变表型推断
16054034 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IGI
IGI: 通过遗传相互作用推断
11948913 MGI
acts upstream of or within canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
11265645 MGI
involved in canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
15265686 MGI
acts upstream of or within canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
20454446 MGI
acts upstream of cell differentiation IMP
IMP: 通过突变表型推断
15581876 MGI
acts upstream of or within cell fate commitment IMP
IMP: 通过突变表型推断
18351662 MGI
acts upstream of or within cellular response to starvation IEP
IEP: 通过表达模式推断
23260145 MGI
acts upstream of or within embryonic epithelial tube formation IDA
IDA: 通过直接分析推断
16546160 MGI
acts upstream of or within female gonad development IMP
IMP: 通过突变表型推断
15162500 MGI
acts upstream of fibroblast growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
16700629 MGI
acts upstream of or within gamete generation IGI
IGI: 通过遗传相互作用推断
15162500 MGI
acts upstream of or within hormone metabolic process IMP
IMP: 通过突变表型推断
12399432 MGI
acts upstream of or within immature T cell proliferation in thymus IMP
IMP: 通过突变表型推断
18617424 MGI
acts upstream of or within kidney morphogenesis IGI
IGI: 通过遗传相互作用推断
23362348 MGI
acts upstream of or within male gonad development IMP
IMP: 通过突变表型推断
15581876 MGI
acts upstream of meiotic nuclear division IGI
IGI: 通过遗传相互作用推断
20106871 MGI
acts upstream of or within mesenchymal to epithelial transition IMP
IMP: 通过突变表型推断
7990960 MGI
acts upstream of or within mesonephric tubule development IGI
IGI: 通过遗传相互作用推断
20040500 MGI
involved in mesonephros development IMP
IMP: 通过突变表型推断
14695376 MGI
acts upstream of or within metanephric nephron development IMP
IMP: 通过突变表型推断
18346943 MGI
acts upstream of or within metanephric nephron morphogenesis IMP
IMP: 通过突变表型推断
19830824 MGI
acts upstream of or within metanephric tubule formation IMP
IMP: 通过突变表型推断
21350016 MGI
acts upstream of or within metanephros development IMP
IMP: 通过突变表型推断
7990960 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12949260 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
19301398 MGI
acts upstream of or within negative regulation of apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
20454446 MGI
acts upstream of or within negative regulation of cell differentiation IMP
IMP: 通过突变表型推断
15581876 MGI
involved in negative regulation of cell migration IGI
IGI: 通过遗传相互作用推断
23027131 MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
16700629 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: 通过突变表型推断
11948913 MGI
involved in negative regulation of testosterone biosynthetic process IMP
IMP: 通过突变表型推断
12949260 MGI
involved in negative regulation of wound healing IGI
IGI: 通过遗传相互作用推断
23027131 MGI
acts upstream of or within nephron development IMP
IMP: 通过突变表型推断
21295565 MGI
acts upstream of or within non-canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
18617424 MGI
acts upstream of or within oocyte development IGI
IGI: 通过遗传相互作用推断
20454446 MGI
acts upstream of or within oocyte development IMP
IMP: 通过突变表型推断
9989404 MGI
acts upstream of or within paramesonephric duct development IMP
IMP: 通过突变表型推断
19830824 MGI
involved in paramesonephric duct development IMP
IMP: 通过突变表型推断
14695376 MGI
acts upstream of or within pericyte cell differentiation IDA
IDA: 通过直接分析推断
16546160 MGI
acts upstream of or within pericyte cell differentiation IMP
IMP: 通过突变表型推断
16546160 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
9356179 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11283799 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
19301398 MGI
involved in positive regulation of GTPase activity IGI
IGI: 通过遗传相互作用推断
23027131 MGI
involved in positive regulation of focal adhesion assembly IGI
IGI: 通过遗传相互作用推断
23027131 MGI
acts upstream of or within positive regulation of meiotic nuclear division IGI
IGI: 通过遗传相互作用推断
20106871 MGI
involved in positive regulation of stress fiber assembly IGI
IGI: 通过遗传相互作用推断
23027131 MGI
acts upstream of or within regulation of cell-cell adhesion IMP
IMP: 通过突变表型推断
20106871 MGI
acts upstream of or within renal vesicle formation IMP
IMP: 通过突变表型推断
16054034 MGI
acts upstream of or within renal vesicle induction IDA
IDA: 通过直接分析推断
11507767 MGI
acts upstream of or within sex differentiation IMP
IMP: 通过突变表型推断
9989404 MGI
acts upstream of or within smooth muscle cell differentiation IDA
IDA: 通过直接分析推断
16546160 MGI
acts upstream of or within smooth muscle cell differentiation IMP
IMP: 通过突变表型推断
16546160 MGI
acts upstream of or within somatotropin secreting cell differentiation IMP
IMP: 通过突变表型推断
18351662 MGI
acts upstream of or within tertiary branching involved in mammary gland duct morphogenesis IMP
IMP: 通过突变表型推断
10733525 MGI
acts upstream of or within thyroid-stimulating hormone-secreting cell differentiation IMP
IMP: 通过突变表型推断
18351662 MGI
acts upstream of or within tube morphogenesis IMP
IMP: 通过突变表型推断
16546160 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
8167409 MGI
located in extracellular matrix IDA
IDA: 通过直接分析推断
8167409 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
23027131 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein Wnt-4

signal molecule

wingless-related MMTV integration site 4

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15836 WNT4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17196 Wnt4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23648 Wnt4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Wnt4 NCBI NCBI:54361
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