PHLDB1 - pleckstrin homology like domain family B member 1 Gene

中文名称：pleckstrin 同源性样域家族 B 成员 1

种属: Homo sapiens

同用名: LL5A; LL5alpha

基因 ID: 23187 | 基因类型: protein coding

关于 PHLDB1

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,606,436-118,658,028 (from NCBI)

This gene has 27 transcripts (splice variants), 325 orthologues and 7 paralogues. Ubiquitous expression in fat (RPKM 23.2), brain (RPKM 15.4) and 23 other tissues.

功能概要

参与胚胎发育的调节；调节上皮间充质转化；和微管细胞骨架组织的调节。位于基底皮质。 [由基因组资源联盟提供，2022 年 4 月]

Involved in regulation of embryonic development; regulation of epithelial to mesenchymal transition; and regulation of microtubule Cytoskeleton organization. Located in basal cortex. [provided by Alliance of Genome Resources, Apr 2022]

PHLDB1 基因产物(3)

mRNA	Protein	Name
NM_001144758.3	NP_001138230.1	pleckstrin homology-like domain family B member 1 isoform a
NM_001144759.3	NP_001138231.1	pleckstrin homology-like domain family B member 1 isoform b
NM_015157.4	NP_055972.1	pleckstrin homology-like domain family B member 1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21653829	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	IGI IGI: 通过遗传相互作用推断	23940118	GOA
involved in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	IMP IMP: 通过突变表型推断	23940118	GOA
involved in regulation of epithelial to mesenchymal transition	IMP IMP: 通过突变表型推断	23940118	GOA
involved in regulation of gastrulation	IMP IMP: 通过突变表型推断	23940118	GOA
involved in regulation of microtubule cytoskeleton organization	IGI IGI: 通过遗传相互作用推断	23940118	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in basal cortex	IDA IDA: 通过直接分析推断	23940118	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PHLDB1 蛋白结构

0
300
600
900
1200
1377 a.a.

蛋白主名

其他名称

pleckstrin homology-like domain family B member 1

protein LL5-alpha

PHLDB1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PHLDB1	Q86UU1	FXR1	Homo sapiens	P51114	Anti Tag CoIP	21653829
种属内	PHLDB1	Q86UU1	FXR1	Homo sapiens	P51114	Y2H Pooling	21653829

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Melanoma-Astrocytoma Syndrome

Melanoma And Neural System Tumor Syndrome	Melanoma Astrocytoma Syndrome
MASTS

Fibroosseous Pseudotumor Of Digits

Fibroosseous Digital Pseudotumor

Fibroosseous Pseudotumor Of The Digits

Mixed Glioma

Mixed Gliomas	Mixed Neuroglial Tumor
Glioma

Enchondromatosis, Multiple, Ollier Type

Ollier Disease	Enchondromatosis
Dyschondroplasia	Osteochondromatosis
Multiple Cartilaginous Enchondroses	Multiple Enchondromatosis
Enchondromatosis With Haemangiomata	Enchondromatosis, Multiple
Kast'S Syndrome	Ollier'S Syndrome
Enchondromatosis Multiple	ENCHOM
Maffucci Disease	Olliers Disease
Hereditary Multiple Exostoses	Chondromatosis

Li-Fraumeni Syndrome

Sarcoma Family Syndrome Of Li And Fraumeni	Sbla Syndrome
LFS	Li-Fraumeni Familiar Cancer Susceptibility Syndrome
Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome	Lfs1
Li Fraumeni Syndrome	Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome
Lfl	Sbla Syndrome Li-Fraumeni-Like Syndrome
Li-Fraumeni Syndrome 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10445	PHLDB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	PHLDB1	VGNC	VGNC:101378
Felis catus	PHLDB1	VGNC	VGNC:64149
Rattus norvegicus	PHLDB1	RGD	RGD:620878
Canis familiaris	PHLDB1	VGNC	VGNC:44502
Bos taurus	PHLDB1	VGNC	VGNC:32837
Mus musculus	PHLDB1	MGD	MGI:2143230

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PHLDB1 - pleckstrin homology like domain family B member 1 Gene

关于 PHLDB1

功能概要

PHLDB1 基因产物(3)

PHLDB1 蛋白结构

PHLDB1 蛋白互作信息

关联疾病

直系同源

热门区域

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PHLDB1 - pleckstrin homology like domain family B member 1 Gene

关于 PHLDB1

功能概要

PHLDB1 基因产物(3)

PHLDB1 蛋白结构

PHLDB1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z