2. Gene
  3. Rbck1 - RanBP-type and C3HC4-type zinc finger containing 1 Gene

Rbck1 - RanBP-type and C3HC4-type zinc finger containing 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: UIP28; HOIL-1; HOIL-1L; Ubce7ip3

基因 ID: 24105 | 基因类型: protein coding

关于 Rbck1

功能概要

Predicted to enable several functions, including protein kinase C binding activity; protein sequestering activity; and ubiquitin binding activity. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NIK/NF-kappaB signaling; and positive regulation of apoptotic process. Acts upstream of or within negative regulation of necroptotic process and positive regulation of extrinsic apoptotic signaling pathway. Predicted to be part of LUBAC complex. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in glycogen storage disease. Orthologous to human RBCK1 (RANBP2-type and C3HC4-type zinc finger containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Rbck1 基因产物(3)

mRNA Protein Name
NM_001083921.1 NP_001077390.1 ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform a
NM_001355282.1 NP_001342211.1 ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform b
NM_019705.3 NP_062679.2 ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20956555 MGI
enables ubiquitin ligase activator activity IDA
IDA: 通过直接分析推断
34755089 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative regulation of necroptotic process IGI
IGI: 通过遗传相互作用推断
22089168 MGI
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
19136968 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
19136968 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
19136968 MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
19136968 MGI
involved in protein polyubiquitination IMP
IMP: 通过突变表型推断
34755089 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of LUBAC complex IDA
IDA: 通过直接分析推断
19136968 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ranBP-type and C3HC4-type zinc finger-containing protein 1

RING-type E3 ubiquitin transferase HOIL-1

heme-oxidized IRP2 ubiquitin ligase 1 homolog

novel zinc finger, C3HC4 type (RING finger) protein

ubcM4-interacting protein 28

ubiquitin-conjugating enzyme 7-interacting protein 3

Rbck1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Rbck1 Q9WUB0 Rnf31 Mus musculus Q924T7
Anti Bait CoIP
21455180
种属内
Rbck1 Q9WUB0 Rnf31 Mus musculus Q924T7
GMS
21455180
种属内
Rbck1 Q9WUB0 Rnf31 Mus musculus Q924T7
GMS
23942237
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11722 RBCK1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20479 Rbck1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26987 Rbck1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rbck1 NCBI NCBI:10616
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