2. Gene
  3. Cacna1c - calcium voltage-gated channel subunit alpha1 C Gene

Cacna1c - calcium voltage-gated channel subunit alpha1 C Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: RATIVS302

基因 ID: 24239 | 基因类型: protein coding

关于 Cacna1c

功能概要

Enables several functions, including high voltage-gated Calcium Channel activity; protein Phosphatase 2A binding activity; and transmembrane transporter binding activity. Involved in calcium ion transport; cellular response to amyloid-beta; and positive regulation of calcium ion transmembrane transport via high voltage-gated Calcium Channel. Located in several cellular components, including T-tubule; postsynaptic density; and synaptic membrane. Part of L-type voltage-gated Calcium Channel complex. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Colocalizes with Z disc. Human ortholog(s) of this gene implicated in Brugada syndrome 3 and Timothy syndrome. Orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C). [provided by Alliance of Genome Resources, Apr 2022]

Cacna1c 基因产物(1)

mRNA Protein Name
NM_012517.2 NP_036649.2 voltage-dependent L-type calcium channel subunit alpha-1C
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables high voltage-gated calcium channel activity IDA
IDA: 通过直接分析推断
17068255 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15140941 RGD
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
14569017 RGD
enables protein phosphatase 2A binding IPI
IPI: 通过物理相互作用推断
16519540 RGD
enables translation initiation factor binding IPI
IPI: 通过物理相互作用推断
23737983 RGD
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
11576544 RGD
enables voltage-gated calcium channel activity IDA
IDA: 通过直接分析推断
15140941 RGD
enables voltage-gated calcium channel activity IMP
IMP: 通过突变表型推断
16483597 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axon development IEP
IEP: 通过表达模式推断
22473424 RGD
involved in calcium ion import IMP
IMP: 通过突变表型推断
19422800 RGD
involved in calcium ion transmembrane transport via high voltage-gated calcium channel IDA
IDA: 通过直接分析推断
15170217 RGD
involved in calcium ion transmembrane transport via high voltage-gated calcium channel IMP
IMP: 通过突变表型推断
18562674 RGD
involved in calcium ion transport IMP
IMP: 通过突变表型推断
16483597 RGD
involved in cellular response to amyloid-beta IEP
IEP: 通过表达模式推断
21822937 RGD
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
22473424 RGD
involved in corpus callosum development IEP
IEP: 通过表达模式推断
22473424 RGD
involved in exocytosis IMP
IMP: 通过突变表型推断
18562674 RGD
involved in optic nerve development IEP
IEP: 通过表达模式推断
22473424 RGD
involved in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IMP
IMP: 通过突变表型推断
25675390 RGD
involved in positive regulation of insulin secretion IMP
IMP: 通过突变表型推断
18562674 RGD
involved in positive regulation of membrane depolarization IMP
IMP: 通过突变表型推断
18562674 RGD
involved in response to alcohol IEP
IEP: 通过表达模式推断
27905406 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
20873977 RGD
involved in response to organic cyclic compound IDA
IDA: 通过直接分析推断
27905406 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of L-type voltage-gated calcium channel complex IDA
IDA: 通过直接分析推断
15170217 RGD
located in T-tubule IDA
IDA: 通过直接分析推断
14569017 RGD
located in Z disc IDA
IDA: 通过直接分析推断
11053140 RGD
located in axon IDA
IDA: 通过直接分析推断
22473424 RGD
located in cell surface IDA
IDA: 通过直接分析推断
21822937 RGD
located in dendrite IDA
IDA: 通过直接分析推断
15140941 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
18067152 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
15140941 RGD
NOT located in nucleus IDA
IDA: 通过直接分析推断
15140941 RGD
located in postsynaptic density IDA
IDA: 通过直接分析推断
15140941 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
18067152 RGD
NOT located in presynaptic membrane IDA
IDA: 通过直接分析推断
15140941 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
18067152 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
17068255 RGD
located in sarcolemma IDA
IDA: 通过直接分析推断
16483597 RGD
part of voltage-gated calcium channel complex IDA
IDA: 通过直接分析推断
16554304 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

voltage-dependent L-type calcium channel subunit alpha-1C

L-type calcium channel alpha-1 subunit

RBC

brain class C

calcium channel, voltage-dependent, L type, alpha 1C subunit

calcium channel, voltage-dependent, alpha 1C subunit

voltage-gated calcium channel subunit alpha Cav1.2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01793 CACNA1C Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21233 Cacna1c Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27750 Cacna1c Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cacna1c NCBI NCBI:775
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