2. Gene
  3. Pfkfb1 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Gene

Pfkfb1 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: PFRX; Pfkfb01

基因 ID: 24638 | 基因类型: protein coding

关于 Pfkfb1

功能概要

Enables several functions, including 6-phosphofructo-2-kinase activity; anion binding activity; and fructose-2,6-bisphosphate 2-phosphatase activity. Involved in several processes, including carbohydrate phosphorylation; positive regulation of Glucokinase activity; and response to peptide hormone. Part of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex. Biomarker of hyperinsulinism. Orthologous to human PFKFB1 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pfkfb1 基因产物(3)

mRNA Protein Name
NM_001271063.1 NP_001257992.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 2
NM_001271064.1 NP_001257993.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 3
NM_012621.4 NP_036753.4 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 6-phosphofructo-2-kinase activity IDA
IDA: 通过直接分析推断
7619077 RGD
enables ATP binding IDA
IDA: 通过直接分析推断
7619077 RGD
enables fructose-2,6-bisphosphate 2-phosphatase activity IDA
IDA: 通过直接分析推断
7619077 RGD
enables fructose-6-phosphate binding IDA
IDA: 通过直接分析推断
7619077 RGD
enables identical protein binding IDA
IDA: 通过直接分析推断
7619077 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
8634242 RGD
enables kinase binding IPI
IPI: 通过物理相互作用推断
11522786 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in animal organ regeneration IEP
IEP: 通过表达模式推断
1315037 RGD
involved in carbohydrate phosphorylation IDA
IDA: 通过直接分析推断
7619077 RGD
involved in positive regulation of glucokinase activity IMP
IMP: 通过突变表型推断
15047617 RGD
involved in positive regulation of glycolytic process through fructose-6-phosphate IMP
IMP: 通过突变表型推断
12230553 RGD
involved in response to cAMP IEP
IEP: 通过表达模式推断
7593243 RGD
involved in response to glucagon IEP
IEP: 通过表达模式推断
7593243 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
7593243 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
8131849 RGD
involved in response to starvation IEP
IEP: 通过表达模式推断
9705027 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex IDA
IDA: 通过直接分析推断
7619077 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

6-PF2-K/Fru-2,6-P2ase

6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase

6PF-2-K/Fru-2,6-P2ASE liver isozyme

6PF-2-K/Fru-2,6-P2ase 1

PFK/FBPase 1

PFK2/FBPase2

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101972 AZ-PFKFB3-67 Inhibitor 97.03% 否
HY-101971 AZ PFKFB3 26 Inhibitor 99.23% 否
HY-101972A AZ-PFKFB3-67 quarterhydrate Inhibitor ≥99.0% 否
HY-RS10361 PFKFB1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20187 Pfkfb1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26691 Pfkfb1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pfkfb1 NCBI NCBI:5207
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