2. Gene
  3. Ccl2 - C-C motif chemokine ligand 2 Gene

Ccl2 - C-C motif chemokine ligand 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: MCP-1; Scya2; Sigje

基因 ID: 24770 | 基因类型: protein coding

关于 Ccl2

功能概要

Enables chemokine activity and heparin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and leukocyte migration. Located in several cellular components, including perikaryon; perinuclear region of cytoplasm; and rough endoplasmic reticulum. Colocalizes with C-fiber. Used to study several diseases, including artery disease (multiple); diabetic angiopathy; interstitial lung disease (multiple); kidney disease (multiple); and pancreatitis (multiple). Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); lung disease (multiple); non-alcoholic fatty liver disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); gastrointestinal system Cancer (multiple); and tuberculosis (multiple). Orthologous to human CCL2 (C-C motif chemokine ligand 2). [provided by Alliance of Genome Resources, Apr 2022]

Ccl2 基因产物(1)

mRNA Protein Name
NM_031530.1 NP_113718.1 C-C motif chemokine 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chemokine activity IDA
IDA: 通过直接分析推断
11104723 RGD
enables heparin binding IPI
IPI: 通过物理相互作用推断
16127145 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in animal organ regeneration IEP
IEP: 通过表达模式推断
19420110 RGD
involved in cellular response to ATP IEP
IEP: 通过表达模式推断
19125410 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: 通过表达模式推断
14512159 RGD
involved in cellular response to estradiol stimulus IEP
IEP: 通过表达模式推断
17237237 RGD
involved in cellular response to fatty acid IEP
IEP: 通过表达模式推断
14656734 RGD
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
26222724 RGD
involved in cellular response to high density lipoprotein particle stimulus IEP
IEP: 通过表达模式推断
18483405 RGD
involved in cellular response to insulin stimulus IEP
IEP: 通过表达模式推断
17180354 RGD
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
14512159 RGD
involved in cellular response to interleukin-6 IEP
IEP: 通过表达模式推断
8921263 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
8921263 RGD
involved in cellular response to lipoprotein particle stimulus IEP
IEP: 通过表达模式推断
11473635 RGD
involved in cellular response to macrophage colony-stimulating factor stimulus IEP
IEP: 通过表达模式推断
8921263 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: 通过表达模式推断
7589574 RGD
involved in cellular response to retinoic acid IEP
IEP: 通过表达模式推断
11274229 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
14512159 RGD
involved in cellular response to type II interferon IEP
IEP: 通过表达模式推断
14512159 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
16331110 RGD
involved in chemokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
18584881 RGD
involved in chronic inflammatory response IEP
IEP: 通过表达模式推断
15104336 RGD
involved in cytokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
16174730 RGD
involved in glial cell migration IMP
IMP: 通过突变表型推断
23010641 RGD
involved in intracellular calcium ion homeostasis IDA
IDA: 通过直接分析推断
15978006 RGD
involved in leukocyte migration involved in inflammatory response IMP
IMP: 通过突变表型推断
8774140 RGD
involved in lymphocyte chemotaxis IDA
IDA: 通过直接分析推断
11104723 RGD
involved in macrophage chemotaxis IDA
IDA: 通过直接分析推断
16127145 RGD
involved in mammary gland involution IEP
IEP: 通过表达模式推断
20110414 RGD
involved in maternal process involved in female pregnancy IEP
IEP: 通过表达模式推断
8788206 RGD
involved in maternal process involved in parturition IEP
IEP: 通过表达模式推断
18606702 RGD
involved in neutrophil chemotaxis IMP
IMP: 通过突变表型推断
16127145 RGD
involved in positive regulation of NMDA glutamate receptor activity IGI
IGI: 通过遗传相互作用推断
27094552 RGD
involved in positive regulation of cell adhesion IDA
IDA: 通过直接分析推断
8103296 RGD
involved in positive regulation of cell-cell adhesion IDA
IDA: 通过直接分析推断
10225970 RGD
involved in positive regulation of cellular extravasation IDA
IDA: 通过直接分析推断
10225970 RGD
involved in positive regulation of collagen biosynthetic process IDA
IDA: 通过直接分析推断
8663511 RGD
involved in positive regulation of endothelial cell proliferation IMP
IMP: 通过突变表型推断
14693680 RGD
involved in positive regulation of leukocyte mediated cytotoxicity IMP
IMP: 通过突变表型推断
8103296 RGD
involved in positive regulation of leukocyte migration IDA
IDA: 通过直接分析推断
7943176 RGD
involved in positive regulation of leukocyte migration IMP
IMP: 通过突变表型推断
14512159 RGD
involved in positive regulation of macrophage chemotaxis IDA
IDA: 通过直接分析推断
9430491 RGD
involved in positive regulation of monocyte chemotaxis IDA
IDA: 通过直接分析推断
1387671 RGD
involved in positive regulation of protein targeting to membrane IDA
IDA: 通过直接分析推断
22222817 RGD
involved in positive regulation of synaptic transmission IDA
IDA: 通过直接分析推断
18584881 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
24826069 RGD
involved in positive regulation of wound healing IMP
IMP: 通过突变表型推断
12831234 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
18797164 RGD
involved in response to amino acid IEP
IEP: 通过表达模式推断
18475188 RGD
involved in response to cyclosporin A IEP
IEP: 通过表达模式推断
15059785 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
17935147 RGD
involved in response to gamma radiation IEP
IEP: 通过表达模式推断
19084914 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
19210118 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
19278353 RGD
involved in response to isolation stress IEP
IEP: 通过表达模式推断
33411841 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
19111613 RGD
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
18606702 RGD
involved in response to progesterone IEP
IEP: 通过表达模式推断
18606702 RGD
involved in response to tumor necrosis factor IEP
IEP: 通过表达模式推断
15855648 RGD
involved in response to vitamin B3 IEP
IEP: 通过表达模式推断
19420110 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
18388116 RGD
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
14505427 RGD
involved in vascular endothelial growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
14693680 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in C-fiber IDA
IDA: 通过直接分析推断
18076762 RGD
located in axon terminus IDA
IDA: 通过直接分析推断
19059387 RGD
located in dendrite IDA
IDA: 通过直接分析推断
16025454 RGD
located in endocytic vesicle IDA
IDA: 通过直接分析推断
12080327 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
19060786 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
15978006 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
16025454 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
14512159 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

C-C motif chemokine 2

chemokine (C-C motif) ligand 2

immediate-early serum-responsive JE protein

immediate-early serum-responsive protein JE

monocyte chemoattractant protein 1

monocyte chemotactic protein 1

small inducible cytokine A2

small inducible gene JE

重组 Ccl2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7236 MCP-1/CCL2 Protein, Rat (HEK293, C-His) P14844 (Q24-N148) ≥95%

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0673 Pirfenidone Inhibitor 99.99% 是
HY-B1322A Amodiaquine 99.98% 否
HY-B1322 Amodiaquine dihydrochloride dihydrate 99.92% 否
HY-B1322B Amodiaquine dihydrochloride 99.97% 否
HY-B0673R Pirfenidone (Standard) Inhibitor 99.97% 否
Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-B0498 Bindarit Inhibitor 99.53% Phase 3
HY-148100A Emapticap pegol sodium Inhibitor 91.38% Phase 2
HY-148100 Emapticap pegol Inhibitor 91.38% Phase 2
HY-B0673S1 Deupirfenidone 99.60% Phase 2
抗体抑制剂 (3)
目录号 产品名 作用方式
纯度 Phase
HY-P99188 Carlumab Inhibitor 97.80% Phase 2
HY-P99450 Avdoralimab Inhibitor 99.25% Phase 2
HY-P99781 Plozalizumab Inhibitor 95.00% Phase 2
Pre-clinical Phase
生物活性分子 (31)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W007376 Indole-3-carboxaldehyde 99.96% 否
HY-120501 B022 Inhibitor 99.37% 否
HY-115644 BMS-470539 dihydrochloride Agonist 99.85% 否
HY-120897 NS-3-008 hydrochloride Inhibitor 99.67% 否
HY-116247 ST247 Agonist 99.88% 否
HY-149202 UT-11 Inhibitor 99.62% 否
HY-160552 244cis 96.70% 否
HY-W013675 2-Methoxyhydroquinone Pre-designed Set 99.57% 否
HY-B0673S Pirfenidone-d5 Inhibitor 98.88% 否
HY-170415 EGR-1-IN-3 Inhibitor 99.13% 否
HY-108554 Q94 hydrochloride Antagonist / 否
HY-121896 DSHN Activator / 否
HY-144334 CHIKV-IN-3 Inhibitor / 否
HY-163655 Glutaminyl Cyclase Inhibitor 6 Inhibitor / 否
HY-171680 Anti-CCL2 (Carlumab)-SMCC-DM1 / 否
HY-171681 Anti-CCL2 (Carlumab)-SPDB-DM4 / 否
HY-171682 Anti-CCL2 (Carlumab)-McMMAF / 否
HY-171683 Anti-CCL2 (Carlumab)-VcMMAE / 否
HY-171684 Anti-CCL2 (Carlumab)-MC-Vc-PAB-SN38 / 否
HY-171685 Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA / 否
HY-171895 12-Nitrolinoleate / 否
HY-175759 EN1033 Inhibitor / 否
HY-176255 TBK1 degrader-4 Inhibitor / 否
HY-B1322AS1 Amodiaquine-d10 hydrochloride / 否
HY-N3887 Evoxine Inhibitor / 否
HY-RS02089 CCL2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W104821 Rosolic acid Activator / 否
HY-168782 Resolvin D2 n-3 DPA Inhibitor / 否
HY-174763 Human CCL2 mRNA / 否
HY-RS16514 Ccl2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22945 Ccl2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990297 Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) Inhibitor 95.00% 否
HY-P99149 Anti-Mouse TNFR2 Antibody (TR75-54.7) Inhibitor ≥95.0% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ccl2 NCBI NCBI:6347
Macaca fascicularis Ccl2 NCBI NCBI:102135739
Mus musculus Ccl2 NCBI NCBI:20296
Susscrofa domestica Ccl2 NCBI
Macaca mulatta Ccl2 NCBI NCBI:574138
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