Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) 

Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is an anti-mouse/rat/human CCL2/MCP-1 IgG monoclonal antibody. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reverse the immunosuppressive microenvironment by blocking the CCL2 signaling pathway. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reduce the secretion of IFN-γ and the infiltration of macrophages. CCL2/MCP-1 Antibody (2H5) can reduce the amount of HIV virus by increasing the proportion of T cells. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can be used for researches on inflammation conditions, virus infection and cancer such as inflammatory bowel disease (IBD), hepatocellular carcinoma (HCC) and HIV^{[1][2][3][4][5]}.

Armenian hamster IgG

Polyclonal Armenian hamster IgG, Isotype Control

Human/Mouse/Rat

CCL2/MCP-1

Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) (5 μg/mL，16 小时) 显著减少 THP-1 细胞向受感染的肠样源性单层 (EDM) 的迁移^[1]。
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) (10 μg/mL，24 小时) 显著降低了间充质基质/干细胞 (MSCs) 对自然杀伤 (NK) 细胞 IFN-γ 分泌的增强作用^[2]。
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) 可以通过敲除 BV2 细胞中的 LILRB4 来抑制 CD8⁺ T 细胞的募集^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) (8 mg/kg，腹腔注射，每周 4 次，从第 18 周至第 24 周) 与 BLZ945 (HY-12768) 联合显著减少了 Diethylnitrosamine (DEN) (HY-N7434) 和 Carbon tetrachloride (CCl₄) (HY-Y0298) 诱导的肝细胞癌的肿瘤数量^[4]。
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) (100-200 μg，腹腔注射，每 48 小时一次，持续 12 天) 显著降低了感染 HIV 病毒的 TKO-BLT 小鼠中的 HIV 病毒量^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

20296  [NCBI]

P10148

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

液体

Colorless to light yellow

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sayed IM, et al. Host engulfment pathway controls inflammation in inflammatory bowel disease. FEBS J. 2020 Sep;287(18):3967-3988.  [Content Brief]

  [2]. Cui R, et al. Human mesenchymal stromal/stem cells acquire immunostimulatory capacity upon cross-talk with natural killer cells and might improve the NK cell function of immunocompromised patients. Stem Cell Res Ther. 2016 Jul 7;7(1):88.  [Content Brief]

  [3]. Ma Y, et al. Microglia LILRB4 upregulation reduces brain damage after acute ischemic stroke by limiting CD8+ T cell recruitment. J Neuroinflammation. 2024 Aug 31;21(1):214.  [Content Brief]

  [4]. Du Y, et al. ASH1L in Hepatoma Cells and Hepatic Stellate Cells Promotes Fibrosis-Associated Hepatocellular Carcinoma by Modulating Tumor-Associated Macrophages. Adv Sci (Weinh). 2024 Dec;11(45):e2404756.  [Content Brief]

  [5]. Packard TA, et al. CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir. mBio. 2022 Oct 26;13(5):e0189122.  [Content Brief]