2. Vitamin D Related/Nuclear Receptor Anti-infection Epigenetics
  3. Nuclear Hormone Receptor 4A/NR4A Parasite Histone Methyltransferase
  4. Amodiaquine

Amodiaquine  (Synonyms: Amodiaquin)

目录号: HY-B1322A 纯度: 99.98%
COA 产品使用指南

摩尔计算器

Amodiaquine (Amodiaquin) 是一种4-氨基喹啉类抗疟剂，是一种有效的具有口服活性的组胺 N-甲基转移酶 (histamine N-methyltransferase) 抑制剂。Amodiaquine 也是一种 Nurr1 激动剂，可特异性结合 Nurr1 的配体结合域，EC50 为 ~20 μM。抗炎作用。

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Amodiaquine Chemical Structure

Amodiaquine Chemical Structure

CAS No. : 86-42-0

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规格 价格 是否有货 数量
5 mg ￥1200
In-stock
10 mg ￥1900
In-stock
50 mg ￥5700
In-stock
100 mg ￥8900
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of Amodiaquine:

Amodiaquine 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4].

IC50 & Target

Plasmodium

 

Nurr1/NR4A2

 

体外研究
(In Vitro)

Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner[1].
Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Amodiaquine 相关抗体:

RT-PCR[1]

Cell Line: Primary microglia
Concentration: 10 µM, 15 µM, 20 µM
Incubation Time: 4 hours
Result: Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
体内研究
(In Vivo)

Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (8-10 weeks of age) induced ntracerebral hemorrhage (ICH)[2]
Dosage: 40 mg/kg
Administration: Intraperitoneal injection; daily; for 3 days
Result: Diminished perihematomal activation of microglia/macrophages and astrocytes.
Clinical Trial
分子量

355.86

Formula

C20H22ClN3O
CAS 号
性状

固体

颜色

White to light yellow

中文名称

阿莫地喹
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 66.67 mg/mL (187.35 mM; ultrasonic and adjust pH to 3 with 1M HCl; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8101 mL 14.0505 mL 28.1009 mL
5 mM 0.5620 mL 2.8101 mL 5.6202 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.98%

COA (177 KB) HNMR (299 KB) LCMS (93 KB)

产品使用指南 (1538 KB)
参考文献

Amodiaquine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8101 mL 14.0505 mL 28.1009 mL 70.2523 mL
5 mM 0.5620 mL 2.8101 mL 5.6202 mL 14.0505 mL
10 mM 0.2810 mL 1.4050 mL 2.8101 mL 7.0252 mL
15 mM 0.1873 mL 0.9367 mL 1.8734 mL 4.6835 mL
20 mM 0.1405 mL 0.7025 mL 1.4050 mL 3.5126 mL
25 mM 0.1124 mL 0.5620 mL 1.1240 mL 2.8101 mL
30 mM 0.0937 mL 0.4683 mL 0.9367 mL 2.3417 mL
40 mM 0.0703 mL 0.3513 mL 0.7025 mL 1.7563 mL
50 mM 0.0562 mL 0.2810 mL 0.5620 mL 1.4050 mL
60 mM 0.0468 mL 0.2342 mL 0.4683 mL 1.1709 mL
80 mM 0.0351 mL 0.1756 mL 0.3513 mL 0.8782 mL
100 mM 0.0281 mL 0.1405 mL 0.2810 mL 0.7025 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amodiaquine86-42-0Amodiaquin阿莫地喹Nuclear Hormone Receptor 4A/NR4AParasiteHistone MethyltransferaseNerve Growth Factor IB-like ReceptorNurr1antimalarialneuroprotectiveIL-1βCCL2CXCL2anti-inflammatoryN-methyltransferaseInhibitorinhibitorinhibit

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