Plozalizumab  (Synonyms: 洛扎利珠单抗; MLN-1202)

Plozalizumab (MLN-1202) is a humanized anti-CCR2 IgG1 monoclonal antibody. Plozalizumab blocks the recruitment of myeloid cells to the tumor microenvironment by inhibiting the CCL2/CCR2 axis. In addition, Plozalizumab can also improve synovial inflammation in rheumatoid arthritis. Plozalizumab can be used in the research of malignant melanoma and bone metastasis-related cancers. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)^[1][2][3].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

729230  [NCBI]

P41597

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

146.08 kDa

1610761-46-0

液体

Colorless to light yellow

洛扎利珠单抗

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

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  Human IgG1 kappa

• 
  Flow cytometric analysis of 1.5*10⁶ THP-1 cells labeling Plozalizumab (HY-P99781, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control.

• [1]. Jahchan NS, et al. Tuning the Tumor Myeloid Microenvironment to Fight Cancer. Front Immunol. 2019 Jul 25;10:1611.  [Content Brief]

  [2]. Majety M, et al. A drug development perspective on targeting tumor-associated myeloid cells. FEBS J. 2018 Feb;285(4):763-776.  [Content Brief]

  [3]. Piehl F. Current and emerging disease-modulatory therapies and treatment targets for multiple sclerosis. J Intern Med. 2021 Jun;289(6):771-791.  [Content Brief]