2. Immunology/Inflammation GPCR/G Protein
  3. Interleukin Related CCR
  4. EN1033

EN1033 是一种共价免疫调节转录因子 5/8 (IRF5/8) 降解剂。EN1033 通过共价靶向半胱氨酸残基 C28 和 C223 来破坏并降解 IRF5 和 IRF8，从而抑制其促炎转录活性，例如降低 IL1A、IL1B 和 CCL2 的 mRNA 水平。EN1033 可用于自身免疫性疾病和炎症性疾病研究。

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EN1033

EN1033 Chemical Structure

CAS No. : 2193367-28-9

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规格 是否有货
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EN1033 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

查看 CCR 亚型特异性产品:

查看所有亚型
CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EN1033 is a covalent Immune regulatory transcription factor 5/8 (IRF5/8) degrader. EN1033 destabilizes and degrades IRF5 and IRF8 by covalently targeting cysteine residues C28 and C223, respectively, inhibiting their pro-inflammatory transcriptional activity, such as the reduced mRNA level of IL1A, IL1B and CCL2. EN1033 can be used for autoimmune and inflammatory diseases research[1].

IC50 & Target[1]

IL-1α

 

IL-1b

 

分子量

242.32

Formula

C15H18N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EN1033 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EN10332193367-28-9EN 1033EN-1033Interleukin RelatedCCRILCC chemokine receptorImmune regulatory transcription factor 5/8IRF5/8Pro-inflammatory transcriptionalAutoimmune and inflammatory diseasesInhibitorinhibitorinhibit

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产品名称：
EN1033
目录号：
HY-175759
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