12-Nitrolinoleate  (Synonyms: 12-Nitro-9-cis,12-cis-octadecadienoic acid)

12-Nitrolinoleate (12-Nitro-9-cis,12-cis-octadecadienoic acid) is an activator for peroxisome proliferator-activated receptor γ (PPARγ). 12-Nitrolinoleate is a nitrated form of linoleic acid. 12-Nitrolinoleate can be formed upon exposure to acidified nitrate and found in human red blood cells and plasma. 12-Nitrolinoleate can activate PPARγ-dependent gene expression in MCF-7 cells expressing PPARγ with an EC₅₀ = 0.045 μM. 12-Nitrolinoleate is able to inhibit LPS (HY-D1056)-induced NF-κB transcription in RAW 264.7 cells. 12-Nitrolinoleate can inhibit IL-6, TNF-α and CCL2 induced by LPS^[1][2][3].

325.44

C₁₈H₃₁NO₄

774603-05-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. 12-Nitrolinoleate (12-Nitro-9-cis,12-cis-octadecadienoic acid) is a peroxisome proliferator-activated receptor γ (PPARγ). 12-Nitrolinoleate is a nitrated form of linoleic acid. 12-Nitrolinoleate can be formed upon exposure to acidified nitrate and found in human red blood cells and plasma. 12-Nitrolinoleate can activate PPARγ-dependent gene expression in MCF-7 cells expressing PPARγ with an EC_{50 = 0.045 μM. 12-Nitrolinoleate is able to inhibit LPS (HY-D1056)-induced NF-κB transcription in RAW 264.7 cells. 12-Nitrolinoleate can inhibit IL-6, TNF-α and CCL2 induced by LPS^[1][2][3].}  [Content Brief]

  [2]. Baker, P. R., et al., (2004). Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation. Proceedings of the National Academy of Sciences of the United States of America, 101(32), 11577–11582.  [Content Brief]

  [3]. Cui, T., et al., (2006). Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators. The Journal of biological chemistry, 281(47), 35686–35698.  [Content Brief]

  [4]. Alexander, R. L., et al., (2009). Differential potencies of naturally occurring regioisomers of nitrolinoleic acid in PPARgamma activation. Biochemistry, 48(2), 492–498.  [Content Brief]