2. Gene
  3. Slc22a1 - solute carrier family 22 member 1 Gene

Slc22a1 - solute carrier family 22 member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Oct1; Orct1; Roct1

基因 ID: 24904 | 基因类型: protein coding

关于 Slc22a1

功能概要

Enables several functions, including cation transmembrane transporter activity; identical protein binding activity; and toxin transmembrane transporter activity. Involved in several processes, including Catecholamine transport; ion transmembrane transport; and toxin transport. Located in apical plasma membrane and basolateral plasma membrane. Is integral component of plasma membrane. Used to study acute kidney failure. Biomarker of asthma; extrahepatic cholestasis; and intrahepatic cholestasis. Orthologous to human SLC22A1 (solute carrier family 22 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a1 基因产物(1)

mRNA Protein Name
NM_012697.1 NP_036829.1 solute carrier family 22 member 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acetylcholine transmembrane transporter activity IDA
IDA: 通过直接分析推断
15817714 RGD
enables dopamine:sodium symporter activity IDA
IDA: 通过直接分析推断
9776363 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18361503 RGD
enables monoamine transmembrane transporter activity IDA
IDA: 通过直接分析推断
8955087 RGD
enables neurotransmitter transmembrane transporter activity IDA
IDA: 通过直接分析推断
15662044 RGD
enables norepinephrine:sodium symporter activity IDA
IDA: 通过直接分析推断
9776363 RGD
enables organic cation transmembrane transporter activity IDA
IDA: 通过直接分析推断
7990927 RGD
enables quaternary ammonium group transmembrane transporter activity IDA
IDA: 通过直接分析推断
8955087 RGD
enables toxin transmembrane transporter activity IMP
IMP: 通过突变表型推断
20477935 RGD
enables xenobiotic transmembrane transporter activity IDA
IDA: 通过直接分析推断
8955087 RGD
enables xenobiotic transmembrane transporter activity IMP
IMP: 通过突变表型推断
20477935 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acetylcholine transport IDA
IDA: 通过直接分析推断
15817714 RGD
involved in cellular detoxification IMP
IMP: 通过突变表型推断
20477935 RGD
involved in dopamine transport IDA
IDA: 通过直接分析推断
9776363 RGD
involved in epinephrine transport IDA
IDA: 通过直接分析推断
9776363 RGD
involved in establishment or maintenance of transmembrane electrochemical gradient IDA
IDA: 通过直接分析推断
15817714 RGD
involved in metanephric proximal tubule development IEP
IEP: 通过表达模式推断
30645697 RGD
involved in monoamine transport IDA
IDA: 通过直接分析推断
9776363 RGD
involved in monoatomic cation transmembrane transport IDA
IDA: 通过直接分析推断
7990927 RGD
involved in norepinephrine transport IDA
IDA: 通过直接分析推断
9776363 RGD
involved in organic cation transport IDA
IDA: 通过直接分析推断
7990927 RGD
involved in quaternary ammonium group transport IDA
IDA: 通过直接分析推断
9776363 RGD
involved in serotonin transport IDA
IDA: 通过直接分析推断
15662044 RGD
involved in xenobiotic transport IDA
IDA: 通过直接分析推断
8955087 RGD
involved in xenobiotic transport IMP
IMP: 通过突变表型推断
20477935 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
15817714 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
7990927 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
12176030 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

solute carrier family 22 member 1

organic cation transporter 1

solute carrier family 22 (organic cation transporter), member 1

Slc22a1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Slc22a1 Q63089 Slc22a1 Rattus norvegicus Q63089
GMS
21896487
种属内
Slc22a1 Q63089 Slc22a1 Rattus norvegicus Q63089
FRET
21896487
种属内
Slc22a1 Q63089 oct1_oat1 Rattus norvegicus EBI-5261357
Pull Down
21896487
种属内
Slc22a1 Q63089 Slc22a1 Rattus norvegicus Q63089
Pull Down
21896487
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13061 SLC22A1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-173231 hURAT1 inhibitor 2 Inhibitor / 否
HY-RS19841 Slc22a1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26339 Slc22a1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc22a1 NCBI NCBI:6580
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