2. Gene
  3. Ptprz1 - protein tyrosine phosphatase, receptor type Z1 Gene

Ptprz1 - protein tyrosine phosphatase, receptor type Z1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Ptpz; RPTPbeta; PTPzeta-A; PTPzeta-B; PTPzeta-S

基因 ID: 25613 | 基因类型: protein coding

关于 Ptprz1

功能概要

Enables Fibroblast Growth Factor binding activity and protein tyrosine Phosphatase activity. Involved in several processes, including nervous system development; positive regulation of cell migration; and regulation of dendrite development. Located in several cellular components, including lamellipodium; perineuronal net; and ruffle membrane. Is intrinsic component of plasma membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Biomarker of amyotrophic lateral sclerosis; middle cerebral artery infarction; status epilepticus; temporal lobe epilepsy; and visual epilepsy. Orthologous to human PTPRZ1 (protein tyrosine Phosphatase receptor type Z1). [provided by Alliance of Genome Resources, Apr 2022]

Ptprz1 基因产物(2)

mRNA Protein Name
NM_001170685.1 NP_001164156.1 receptor-type tyrosine-protein phosphatase zeta isoform 2 precursor
NM_013080.2 NP_037212.2 receptor-type tyrosine-protein phosphatase zeta isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables fibroblast growth factor binding IPI
IPI: 通过物理相互作用推断
9705269 RGD
enables phosphatase activity IDA
IDA: 通过直接分析推断
17646177 RGD
enables phosphatase activity IMP
IMP: 通过突变表型推断
30667096 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
8702927 RGD
enables protein tyrosine phosphatase activity IDA
IDA: 通过直接分析推断
11381105 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axonal fasciculation IDA
IDA: 通过直接分析推断
16150606 RGD
involved in hippocampus development IEP
IEP: 通过表达模式推断
10906718 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
9809586 RGD
involved in negative regulation of cell-substrate adhesion IDA
IDA: 通过直接分析推断
12821372 RGD
involved in negative regulation of dendrite development IDA
IDA: 通过直接分析推断
11431463 RGD
involved in neuron development IEP
IEP: 通过表达模式推断
15708477 RGD
involved in oligodendrocyte differentiation IEP
IEP: 通过表达模式推断
8812065 RGD
involved in peptidyl-tyrosine dephosphorylation IDA
IDA: 通过直接分析推断
16814777 RGD
involved in positive regulation of Schwann cell migration IMP
IMP: 通过突变表型推断
11520897 RGD
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
11340082 RGD
involved in positive regulation of dendrite development IDA
IDA: 通过直接分析推断
8625816 RGD
involved in positive regulation of fibroblast proliferation IDA
IDA: 通过直接分析推断
9705269 RGD
involved in positive regulation of neuron migration IMP
IMP: 通过突变表型推断
9660874 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
8702927 RGD
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
30667096 RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
8625816 RGD
involved in protein dephosphorylation IDA
IDA: 通过直接分析推断
11381105 RGD
involved in regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
12684467 RGD
involved in visual learning IEP
IEP: 通过表达模式推断
12737936 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
15708477 RGD
located in dendrite IDA
IDA: 通过直接分析推断
15708477 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
15982644 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
15708477 RGD
located in filopodium IDA
IDA: 通过直接分析推断
9660874 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
15982644 RGD
located in growth cone IDA
IDA: 通过直接分析推断
8702927 RGD
located in lamellipodium IDA
IDA: 通过直接分析推断
9660874 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
8702927 RGD
located in perineuronal net IDA
IDA: 通过直接分析推断
16644727 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
16814777 RGD
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
15982644 RGD
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
15982644 RGD
located in ruffle membrane IDA
IDA: 通过直接分析推断
11381105 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

receptor-type tyrosine-protein phosphatase zeta

3F8 chondroitin sulfate proteoglycan

3H1 keratan sulfate proteoglycan

6B4 proteoglycan

PTP zeta

R-PTP-zeta

protein tyrosine phosphatase, receptor-type, Z polypeptide 1

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103693 NAZ2329 Inhibitor 99.02% 否
HY-123856 MY10 99.87% 否
HY-RS11452 PTPRZ1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17478 Ptprz1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23936 Ptprz1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptprz1 NCBI NCBI:5803
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