2. Gene
  3. CLIC4 - chloride intracellular channel 4 Gene

CLIC4 - chloride intracellular channel 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：氯离子细胞内通道 4

种属: Homo sapiens

同用名: H1; huH1; p64H1; CLIC4L; MTCLIC

基因 ID: 25932 | 基因类型: protein coding

关于 CLIC4

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:24,745,447-24,844,321 (from NCBI)

This gene has 4 transcripts (splice variants), 257 orthologues and 14 paralogues. Ubiquitous expression in endometrium (RPKM 129.1), kidney (RPKM 121.8) and 25 other tissues.

功能概要

氯离子通道是一组不同的蛋白质，可调节基本细胞过程，包括稳定细胞膜电位、跨上皮转运、维持细胞内 pH 值和调节细胞体积。由 CLIC4 基因编码的氯化物细胞内通道 4 (CLIC4) 蛋白是 p64 家族的成员；该基因在许多组织中表达，并在 Panc-1 细胞 (胰腺癌细胞) 中表现出细胞内囊泡模式。[RefSeq 提供，2008 年 7 月]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic Cancer cells). [provided by RefSeq, Jul 2008]

CLIC4 基因产物(1)

mRNA Protein Name
NM_013943.3 NP_039234.1 chloride intracellular channel protein 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10793131 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to calcium ion IMP
IMP: 通过突变表型推断
17636002 GOA
involved in keratinocyte differentiation IMP
IMP: 通过突变表型推断
17636002 GOA
involved in negative regulation of cell migration IDA
IDA: 通过直接分析推断
12163372 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
14569596 GOA
located in cell surface IDA
IDA: 通过直接分析推断
14569596 GOA
located in cell-cell junction IDA
IDA: 通过直接分析推断
14569596 GOA
located in centrosome IDA
IDA: 通过直接分析推断
14569596 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
10793131 GOA
located in cytosol IDA
IDA: 通过直接分析推断
10026142 GOA
colocalizes with microtubule cytoskeleton IDA
IDA: 通过直接分析推断
14569596 GOA
located in microvillus IDA
IDA: 通过直接分析推断
14569596 GOA
located in midbody IDA
IDA: 通过直接分析推断
14569596 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
14569596 GOA
located in nuclear matrix IDA
IDA: 通过直接分析推断
14569596 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
14569596 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
19776349 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLIC4 蛋白结构

GST_N_3

GST_N_3: Glutathione S-transferase, N-terminal domain (35 - 97)

  • 0
  • 100
  • 200
  • 253 a.a.
蛋白主名 其他名称

chloride intracellular channel protein 4

chloride intracellular channel 4 like

CLIC4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CLIC4 Q9Y696 TPRN Homo sapiens Q4KMQ1-2
Anti Tag CoIP
28514442
种属内
CLIC4 Q9Y696 TPRN Homo sapiens Q4KMQ1-2
Y2H Array
32296183
种属内
CLIC4 Q9Y696 TPRN Homo sapiens Q4KMQ1-2
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CLIC4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70120 CLIC4/Chloride intracellular channel 4 Protein, Human (His) Q9Y696 (M1-K253) ≥95%

CLIC4 抗体

目录号 产品名 应用 反应物种
HY-P82772 CLIC4 Antibody (YA2517) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02806 CLIC4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20381 Clic4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26891 Clic4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CLIC4 RGD RGD:61857
Macaca mulatta CLIC4 VGNC VGNC:71172
Mus musculus CLIC4 MGD MGI:1352754
Bos taurus CLIC4 VGNC VGNC:27442
Canis familiaris CLIC4 VGNC VGNC:39340
Others CLIC4 NCBI
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