1. Gene
  2. SERGEF - secretion regulating guanine nucleotide exchange factor Gene

SERGEF - secretion regulating guanine nucleotide exchange factor Gene

中文名称:分泌调节鸟嘌呤核苷酸交换因子

种属: Homo sapiens

同用名: Gnefr; DELGEF

基因 ID: 26297 | 基因类型: protein coding

关于 SERGEF

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:17,788,048-18,013,047 (from NCBI)

This gene has 23 transcripts (splice variants), 196 orthologues and 9 paralogues. Ubiquitous expression in brain (RPKM 11.3), thyroid (RPKM 11.2) and 25 other tissues.

功能概要

预测可启用胍基核苷酸交换因子活性。参与蛋白质分泌的负调节。位于细胞质和核质中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in negative regulation of protein secretion. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SERGEF 基因产物(1)

mRNA Protein Name
NM_012139.4 NP_036271.1 secretion-regulating guanine nucleotide exchange factor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12459492 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of protein secretion IDA
IDA: 通过直接分析推断
12459492 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10571079 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10571079 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SERGEF 蛋白结构

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (17 - 64)

RCC1_2

RCC1_2: Regulator of chromosome condensation (RCC1) repeat (105 - 132)

RCC1_2

RCC1_2: Regulator of chromosome condensation (RCC1) repeat (219 - 243)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (284 - 348)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (351 - 399)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
蛋白主名 其他名称

secretion-regulating guanine nucleotide exchange factor

deafness locus associated putative guanine nucleotide exchange factor

SERGEF 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SERGEF Q9UGK8 DPH3 Homo sapiens Q96FX2
Y2H
14980502
种属内
SERGEF Q9UGK8 PRMT6 Homo sapiens Q96LA8 23455924
种属内
SERGEF Q9UGK8 PRMT6 Homo sapiens Q96LA8
Y2H
23455924
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Theileriasis

Theileriosis

Infection By Theileria

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SERGEF RGD RGD:1563497
Felis catus SERGEF VGNC VGNC:81941
Mus musculus SERGEF MGD MGI:1351630
Bos taurus SERGEF VGNC VGNC:50043
Macaca mulatta SERGEF VGNC VGNC:77258