2. Gene
  3. Aifm1 - apoptosis-inducing factor, mitochondrion-associated 1 Gene

Aifm1 - apoptosis-inducing factor, mitochondrion-associated 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Hq; AIF; Pdcd8; AIFsh2

基因 ID: 26926 | 基因类型: protein coding

关于 Aifm1

功能概要

Enables DNA binding activity; FAD binding activity; and NAD(P)H oxidase H2O2-forming activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; mitochondrion organization; and positive regulation of cell death. Acts upstream of or within neuron apoptotic process and regulation of apoptotic DNA fragmentation. Located in cytosol; mitochondrion; and nucleus. Is expressed in several structures, including early embryo; liver; and retina. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined Oxidative Phosphorylation deficiency 6. Orthologous to several human genes including TXNDC12 (thioredoxin domain containing 12). [provided by Alliance of Genome Resources, Apr 2022]

Aifm1 基因产物(2)

mRNA Protein Name
NM_001290364.1 NP_001277293.1 apoptosis-inducing factor 1, mitochondrial isoform 2
NM_012019.3 NP_036149.1 apoptosis-inducing factor 1, mitochondrial isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
21467298 MGI
enables FAD binding IDA
IDA: 通过直接分析推断
21467298 MGI
enables NAD(P)H oxidase H2O2-forming activity IDA
IDA: 通过直接分析推断
21467298 MGI
enables poly-ADP-D-ribose binding IDA
IDA: 通过直接分析推断
21467298 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18056262 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
18056262 MGI
involved in mitochondrial respiratory chain complex assembly IMP
IMP: 通过突变表型推断
26004228 MGI
acts upstream of or within neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
15703386 MGI
involved in positive regulation of necroptotic process IDA
IDA: 通过直接分析推断
12114629 MGI
involved in protein import into mitochondrial intermembrane space IMP
IMP: 通过突变表型推断
26004228 MGI
acts upstream of or within regulation of apoptotic DNA fragmentation IGI
IGI: 通过遗传相互作用推断
15703386 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
14707049 MGI
located in cytosol IDA
IDA: 通过直接分析推断
18056262 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
15271982 MGI
located in mitochondrion IMP
IMP: 通过突变表型推断
21467298 MGI
is active in nucleus IDA
IDA: 通过直接分析推断
12114629 MGI
located in nucleus IDA
IDA: 通过直接分析推断
14707049 MGI
located in nucleus IMP
IMP: 通过突变表型推断
21467298 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

apoptosis-inducing factor 1, mitochondrial

harlequin

programmed cell death protein 8

Aifm1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Aifm1 Q9Z0X1 H2ax Mus musculus P27661
Anti Bait CoIP
20360685
种属内
Aifm1 Q9Z0X1 Tsc22d4 Mus musculus Q9EQN3
Cosedimentation
23305244
种属内
Aifm1 Q9Z0X1 Tsc22d4 Mus musculus Q9EQN3
Anti Bait CoIP
23305244
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00492 AIFM1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19406 Aifm1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25898 Aifm1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Aifm1 NCBI NCBI:9131
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