MORC1 - MORC family CW-type zinc finger 1 Gene

中文名称：MORC 家族 CW 型锌指 1

种属: Homo sapiens

同用名: CT33; MORC; ZCW6

基因 ID: 27136 | 基因类型: protein coding

关于 MORC1

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:108,958,248-109,118,134 (from NCBI)

This gene has 2 transcripts (splice variants), 86 orthologues and 1 paralogue. Restricted expression toward testis (RPKM 9.4).

功能概要

该基因编码小鼠 morc 的人类同系物，与小鼠蛋白质一样，它是睾丸特异性的。小鼠研究支持睾丸特异性功能，因为只有雄性基因敲除小鼠不育；不孕症是唯一明显的缺陷。这些研究进一步支持这种蛋白质在精子发生早期的作用，可能是通过影响细胞凋亡的进入，因为敲除小鼠的睾丸显示凋亡细胞数量大大增加。[RefSeq 提供，2009 年 1 月]

This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into Apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]

MORC1 基因产物(1)

mRNA	Protein	Name
NM_014429.4	NP_055244.3	MORC family CW-type zinc finger protein 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MORC1 蛋白结构

HATPase_c_3

zf-CW

0
200
400
600
800
984 a.a.

蛋白主名

其他名称

MORC family CW-type zinc finger protein 1

cancer/testis antigen 33

MORC1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MORC1	Q86VD1	MORC2	Homo sapiens	Q9Y6X9	Anti Tag CoIP	33961781
种属内	MORC1	Q86VD1	MORC2	Homo sapiens	Q9Y6X9	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Charcot-Marie-Tooth Disease, Axonal, Type 2z

CMT2Z	Charcot-Marie-Tooth Disease Axonal Type 2z
Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2z	Charcot-Marie-Tooth Neuropathy, Type 2z
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2z	Charcot-Marie-Tooth Neuropathy Type 2z
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2z	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Morc2 Mutation
Charcot-Marie-Tooth Disease 2z	Charcot-Marie-Tooth Disease, Type 2z

Charcot-Marie-Tooth Disease, X-Linked Recessive, 3

CMTX3	Charcot-Marie-Tooth Disease X-Linked Recessive 3
Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 3	Cmt3x
X-Linked Charcot-Marie-Tooth Disease Type 3	Charcot-Marie-Tooth Neuropathy X-Linked Recessive 3
Charcot-Marie-Tooth Disease, X-Linked Type 3, Recessive

Holoprosencephaly 1

Arhinencephaly	HPE1
Cyclopia	Holoprosencephaly, Familial Alobar
Hpe, Familial	Hpec
Demyer Sequence	Holoprosencephaly-1

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08589	MORC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS22647	Morc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	MORC1	RGD	RGD:1565610
Felis catus	MORC1	VGNC	VGNC:68299
Canis familiaris	MORC1	VGNC	VGNC:43316
Bos taurus	MORC1	VGNC	VGNC:31554
Macaca mulatta	MORC1	VGNC	VGNC:74910
Mus musculus	MORC1	MGD	MGI:1316740

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