OXGR1 - oxoglutarate receptor 1 Gene

中文名称：氧化戊二酸受体 1

种属: Homo sapiens

同用名: aKGR; GPR80; GPR99; P2Y15; P2RY15

关于 OXGR1

功能概要

该基因编码 G 蛋白偶联受体 (GPCR) ，属于 GPCR 超家族中的氧化戊二酸受体家族。编码的蛋白质被柠檬酸中间体、酮戊二酸以及几种半胱氨酰白三烯激活，包括白三烯 E4、C4 和 D4，它们与许多炎症性疾病有关。在小鼠中，该基因的敲除会导致中耳炎症、粘膜上皮细胞发生变化以及鼓膜后液体增加，并与听力损失有关。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 10 月]

This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily. The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. In mice, a knock-out of this gene leads to middle ear inflammation, changes in the mucosal epithelium, and an increase in fluid behind the eardrum, and is associated with hearing loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]