1. Gene
  2. HTRA2 - HtrA serine peptidase 2 Gene

HTRA2 - HtrA serine peptidase 2 Gene

中文名称:HtrA 丝氨酸肽酶 2

种属: Homo sapiens

同用名: OMI; MGCA8; PARK13; PRSS25

基因 ID: 27429 | 基因类型: protein coding

关于 HTRA2

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,529,405-74,533,556 (from NCBI)

This gene has 17 transcripts (splice variants), 195 orthologues, 3 paralogues and is associated with 5 phenotypes. Ubiquitous expression in spleen (RPKM 12.3), bone marrow (RPKM 11.8) and 25 other tissues.

功能概要

该基因编码一种丝氨酸蛋白酶。该蛋白定位于内质网,并与有丝分裂原活化蛋白激酶 14 的可变剪接形式相互作用。该蛋白还定位于线粒体,并在细胞凋亡刺激后释放到胞质溶胶中。该蛋白被认为通过结合细胞凋亡抑制蛋白杆状病毒 IAP 重复序列 4 来诱导细胞凋亡。还观察到了该蛋白的核定位。该基因的交替剪接导致编码不同亚型的多个转录变体。[RefSeq 提供,2016 年 3 月]

This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce Apoptosis by binding the Apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

HTRA2 基因产物(4)

mRNA Protein Name
NM_001321727.1 NP_001308656.1 serine protease HTRA2, mitochondrial isoform 3 preproprotein
NM_001321728.1 NP_001308657.1 serine protease HTRA2, mitochondrial isoform 4 preproprotein
NM_013247.5 NP_037379.1 serine protease HTRA2, mitochondrial isoform 1 preproprotein
NM_145074.2 NP_659540.1 serine protease HTRA2, mitochondrial isoform 2 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
11967569 GOA
enables peptidase activity IDA
IDA: 通过直接分析推断
11604410 GOA
enables peptidase activity IMP
IMP: 通过突变表型推断
24709290 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10971580 GOA
enables protein serine/threonine kinase inhibitor activity IDA
IDA: 通过直接分析推断
25118933 GOA
enables serine-type endopeptidase activity IDA
IDA: 通过直接分析推断
11602612 GOA
enables serine-type endopeptidase activity IMP
IMP: 通过突变表型推断
10971580 GOA
enables serine-type peptidase activity IDA
IDA: 通过直接分析推断
11583623 GOA
enables ubiquitin ligase inhibitor activity IDA
IDA: 通过直接分析推断
11602612 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to growth factor stimulus IMP
IMP: 通过突变表型推断
20125124 GOA
involved in cellular response to heat IDA
IDA: 通过直接分析推断
10971580 GOA
involved in cellular response to interferon-beta IDA
IDA: 通过直接分析推断
17297443 GOA
involved in cellular response to oxidative stress IMP
IMP: 通过突变表型推断
24709290 GOA
involved in cellular response to retinoic acid IDA
IDA: 通过直接分析推断
17297443 GOA
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
25118933 GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
11602612 GOA
involved in mitochondrion organization IMP
IMP: 通过突变表型推断
25118933 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
11967569 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
11583623 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
11967569 GOA
involved in positive regulation of execution phase of apoptosis IDA
IDA: 通过直接分析推断
17297443 GOA
involved in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: 通过突变表型推断
20125124 GOA
involved in programmed cell death IDA
IDA: 通过直接分析推断
11583623 GOA
involved in protein catabolic process IDA
IDA: 通过直接分析推断
17297443 GOA
involved in proteolysis IMP
IMP: 通过突变表型推断
10971580 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
24798695 GOA
located in cytoskeleton IDA
IDA: 通过直接分析推断
24798695 GOA
located in cytosol IDA
IDA: 通过直接分析推断
11583623 GOA
located in membrane IDA
IDA: 通过直接分析推断
24798695 GOA
located in mitochondrial intermembrane space IDA
IDA: 通过直接分析推断
15044455 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
11583623 GOA
located in mitochondrion IMP
IMP: 通过突变表型推断
11604410 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10971580 GOA
part of serine-type endopeptidase complex IMP
IMP: 通过突变表型推断
11967569 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HTRA2 蛋白结构

Trypsin_2

Trypsin_2: Trypsin-like peptidase domain (182 - 320)

PDZ_2

PDZ_2: PDZ domain (361 - 453)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
蛋白主名 其他名称

serine protease HTRA2, mitochondrial

HtrA-like serine protease

HTRA2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HTRA2 O43464 PSMC3 Homo sapiens P17980 32814053
种属内
HTRA2 O43464 PSMC3 Homo sapiens P17980 32814053
种属内
HTRA2 O43464 PSMC3 Homo sapiens P17980 32814053
种属内
HTRA2 O43464 NDUFA13 Homo sapiens Q9P0J0 31617661
种属内
HTRA2 O43464 NDUFA13 Homo sapiens Q9P0J0 17297443
种属内
HTRA2 O43464 NDUFA13 Homo sapiens Q9P0J0 17297443
种属内
HTRA2 O43464 NDUFA13 Homo sapiens Q9P0J0
Y2H
17297443
种属内
HTRA2 O43464 SMN1 Homo sapiens Q16637-3 32814053
种属内
HTRA2 O43464 SMN1 Homo sapiens Q16637-3 32814053
种属内
HTRA2 O43464 SMN1 Homo sapiens Q16637-3 32814053
种属内
HTRA2 O43464 BIRC2 Homo sapiens Q13490 31617661
种属内
HTRA2 O43464 XIAP Homo sapiens P98170
SPR
24698088
种属内
HTRA2 O43464 XIAP Homo sapiens P98170 31617661
种属内
HTRA2 O43464 XIAP Homo sapiens P98170 28642151
种属内
HTRA2 O43464 XIAP Homo sapiens P98170
FPS
11801603
种属内
HTRA2 O43464 XIAP Homo sapiens P98170 11583623
种属内
HTRA2 O43464 XIAP Homo sapiens P98170 11801603
种属内
HTRA2 O43464 XIAP Homo sapiens P98170 11604410
种属内
HTRA2 O43464 XIAP Homo sapiens P98170 24698088
种属内
HTRA2 O43464 XIAP Homo sapiens P98170 11602612
种属间
HTRA2 O43464 Ripk1 Mus musculus Q60855 20125124
种属内
HTRA2 O43464 TTC19 Homo sapiens Q6DKK2 31617661
种属间
HTRA2 O43464 CSN2 Bos taurus P02666 28642151
种属间
HTRA2 O43464 CSN2 Bos taurus P02666 10971580
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 HTRA2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74876 HTRA2/OMI Protein, Human (His) O43464 (A134-E458) ≥95%

HTRA2 抗体

目录号 产品名 应用 反应物种
HY-P80715 HtrA2/Omi Antibody (YA726) WB, IP Human
HY-P83839 HtrA2/Omi Antibody (YA3536) WB, IHC-P, FC, ELISA Human, Mouse, Rat
HY-P85595 HtrA2/Omi Antibody (YA5287) WB Human
HY-P85641 HtrA2/Omi Antibody (YA5333) WB Mouse, Hamster

关联疾病

疾病名称 别名
3-Methylglutaconic Aciduria, Type Viii

3-Methylglutaconic Aciduria Type 8

MGCA8

3-Methylglutaconic Aciduria Type Viii, Mgca8

Mga8

3-Methylglutaconic Aciduria 8

3-Methylglutaconic Aciduria, Type Vii

Parkinson Disease 13, Autosomal Dominant

Parkinson Disease 13

Parkinson Disease 13, Autosomal Dominant, Susceptibility To

PARK13

Parkinson Disease, Type 13

3-Methylglutaconic Aciduria

3-Methyl Glutaconic Aciduria

Parkinson Disease 2, Autosomal Recessive Juvenile

Young-Onset Parkinson Disease

PARK2

Pdj

Autosomal Recessive Juvenile Parkinson Disease 2

Epdf

Parkinson Disease, Juvenile, Type 2

Parkinson'S Disease 2

Autosomal Recessive Juvenile Parkinson Disease

Early-Onset Parkinson Disease

Parkinson Disease 2

Parkinson Disease, Juvenile, Autosomal Recessive

Parkinsonism, Early-Onset, With Diurnal Fluctuation

Autosomal Recessive Juvenile Parkinson'S Disease 2

Jp

Juvenile Parkinsonism

Parkinson Disease Autosomal Recessive, Early Onset

Parkinsonism, Early Onset, With Diurnal Fluctuation

Yopd

Autosomal Recessive Early-Onset Parkinson Disease Type 2

Chromosome 6-Linked Autosomal Recessive Parkinsonism

Early-Onset Parkinsonism With Diurnal Fluctuation

Parkinsonism Young Adult Onset

Parkinson Disease, Type 2

Parkinsonism, Juvenile

Tremor

Medicament-Induced Tremor

Medication-Induced Postural Tremor

Essential Tremor

Benign Essential Tremor

Familial Tremor

Hereditary Essential Tremor

Essential Hereditary Tremor

Shaky Hand Syndrome

Benign Essential Tremor Syndrome

Tremor Hereditary Essential

Essential Tremor, Susceptibility To

Tremor, Hereditary Essential

Tremor, Hereditary Essential, 1

ETM1

Fet1

Essential Tremor 1

Tremor, Familial Essential, 1

Essential Tremor, Hereditary, 1

Hereditary Essential Tremor 1

Tremor Hereditary Essential, 1

Tremor Familial Essential, 1

Tremor, Hereditary Essential 1

Tremor, Essential Hereditary, Type 1

Parkinson Disease 3, Autosomal Dominant

PARK3

Parkinson Disease 3

Parkinson Disease 3, Autosomal Dominant Lewy Body

Parkinson'S Disease 3

Autosomal Dominant Lewy Body Parkinson Disease 3

Autosomal Dominant Parkinson Disease 3

Parkinson Disease Type 3

Autosomal Dominant Parkinson Disease

Parkinson Disease, Autosomal Dominant

Parkinson Disease, Familial, Type 1

3-Methylglutaconic Aciduria With Cataracts, Neurologic Involvement And Neutropenia

3-Methylglutaconic Aciduria Type 7

Mga7

3-Methylglutaconic Aciduria Type Vii

Megcann

Mgca7

3-Methylglutaconic Aciduria-Cataract-Neurologic Involvement-Neutropenia Syndrome

3-Methylglutaconic Aciduria With Cataracts, Neurologic Involvement, And Neutropenia

Parkinsonism

Parkinsonism-Plus

Idiopathic Parkinsonism

Primary Parkinsonism

Paralysis Agitans Syndrome

Parkinsonian Syndrome

Trembling Paralysis

Paralysis Agitans

Shaking Palsy

Shaking Paralysis

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Combat Disorder

Combat Disorders

Combat Neurosis

3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy

3-Methylglutaconic Aciduria Type 3

Costeff Syndrome

Mga3

Costeff Optic Atrophy Syndrome

Optic Atrophy Plus Syndrome

Infantile Optic Atrophy With Chorea And Spastic Paraplegia

3-Methylglutaconic Aciduria Type Iii

Autosomal Recessive Optic Atrophy Plus Syndrome

Autosomal Recessive Optic Atrophy Type 3

Opa3 Defect

MGCA3

Mga, Type Iii

Iraqi Jewish Optic Atrophy Plus

Mga Type Iii

Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia

Iraqi-Jewish 'Optic Atrophy Plus'

Optic Atrophy 3, Autosomal Recessive

Opa3, Autosomal Recessive

Opa3-Related 3-Methylglutaconic Aciduria

Iraqi-Jewish Optic Atrophy Plus

Atrophy Of Optic Disc

3-Alpha Methylglutaconic Aciduria Type Iii

Optic Atrophy 3

Optic Atrophy Infantile With Chorea And Spastic Paraplegia

Autosomal Recessive Opa3

Autosomal Recessive Optic Atrophy 3

3-Methylglutaconic Aciduria 3

3-Alpha-Methylglutaconic Aciduria Type 3

Optic Atrophy 3 Autosomal Recessive

Atrophy, Optic

Atrophy, Optic, Plus Syndrome

Optic Nerve Atrophy

Primary Optic Atrophy

Oa - [Optic Atrophy]

Second Cranial Nerve Atrophy

Second Cranium Nerve Atrophy

Movement Disease

Movement Disorders

Movement Disorder

Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris HTRA2 VGNC VGNC:41836
Rattus norvegicus HTRA2 RGD RGD:1308906
Felis catus HTRA2 VGNC VGNC:62855
Macaca mulatta HTRA2 VGNC VGNC:73390
Bos taurus HTRA2 VGNC VGNC:30005
Mus musculus HTRA2 MGD MGI:1928676
Others HTRA2 NCBI