IFNL1 - interferon lambda 1 Gene

中文名称：干扰素λ1

种属: Homo sapiens

同用名: IL29; IL-29

关于 IFNL1

功能概要

该基因编码与 I 型干扰素和 IL-10 家族远缘的细胞因子。该基因、白细胞介素 28A (IL28A) 和白细胞介素 28B (IL28B) 是三个密切相关的细胞因子基因，它们在映射到 19q13 的染色体区域上形成细胞因子基因簇。病毒感染可诱导这三个基因编码的细胞因子的表达。所有三种细胞因子均已显示与异二聚体 II 类细胞因子受体相互作用，该受体由白细胞介素 10 受体 β (IL10RB) 和白细胞介素 28 受体 α (IL28RA) 组成。[RefSeq 提供，2008 年 7 月]

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral Infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]