2. Gene
  3. Hfe - homeostatic iron regulator Gene

Hfe - homeostatic iron regulator Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 29199 | 基因类型: protein coding

关于 Hfe

功能概要

Predicted to enable beta-2-microglobulin binding activity; co-receptor binding activity; and Transferrin Receptor binding activity. Involved in several processes, including acute-phase response; liver regeneration; and response to starvation. Located in apical part of cell; plasma membrane; and terminal web. Human ortholog(s) of this gene implicated in several diseases, including acute porphyria (multiple); arthritis (multiple); bone marrow Cancer (multiple); hemochromatosis (multiple); and liver disease (multiple). Orthologous to human HFE (homeostatic iron regulator). [provided by Alliance of Genome Resources, Apr 2022]

Hfe 基因产物(6)

mRNA Protein Name
NM_001173434.1 NP_001166905.1 hereditary hemochromatosis protein homolog isoform 2 precursor
NM_001173435.1 NP_001166906.1 hereditary hemochromatosis protein homolog isoform 3 precursor
NM_053301.4 NP_445753.1 hereditary hemochromatosis protein homolog isoform 1 precursor
NM_001173434.1 NP_001166905.1 hereditary hemochromatosis protein homolog isoform 2 precursor
NM_001173435.1 NP_001166906.1 hereditary hemochromatosis protein homolog isoform 3 precursor
NM_053301.4 NP_445753.1 hereditary hemochromatosis protein homolog isoform 1 precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acute-phase response IEP
IEP: 通过表达模式推断
22469696 RGD
involved in cellular response to iron ion starvation IEP
IEP: 通过表达模式推断
16208485 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
15082582 RGD
involved in liver regeneration IEP
IEP: 通过表达模式推断
22364558 RGD
involved in multicellular organismal-level iron ion homeostasis IEP
IEP: 通过表达模式推断
15082582 RGD
involved in response to iron ion starvation IEP
IEP: 通过表达模式推断
16208485 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
16208485 RGD
NOT located in microvillus membrane IDA
IDA: 通过直接分析推断
16208485 RGD
located in terminal web IDA
IDA: 通过直接分析推断
16208485 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

hereditary hemochromatosis protein homolog

RT1-CAFE

hemochromatosis

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06149 HFE Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18894 Hfe Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25385 Hfe Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991716 Selcodebart Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hfe NCBI NCBI:3077
Macaca fascicularis Hfe NCBI NCBI:102139119
Mus musculus Hfe NCBI NCBI:15216
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