2. Gene
  3. Adra1a - adrenoceptor alpha 1A Gene

Adra1a - adrenoceptor alpha 1A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Adra1c

基因 ID: 29412 | 基因类型: protein coding

关于 Adra1a

功能概要

Enables alpha1-adrenergic receptor activity. Involved in several processes, including activation of Phospholipase C activity; positive regulation of cell communication; and regulation of blood circulation. Acts upstream of or within negative regulation of Rho protein signal transduction. Located in T-tubule and Z disc. Is active in GABA-ergic synapse; dopaminergic synapse; and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study bladder neck obstruction. Biomarker of hypertension and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease and hypertension. Orthologous to human ADRA1A (adrenoceptor alpha 1A). [provided by Alliance of Genome Resources, Apr 2022]

Adra1a 基因产物(1)

mRNA Protein Name
NM_017191.2 NP_058887.2 alpha-1A adrenergic receptor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative regulation of Rho protein signal transduction IMP
IMP: 通过突变表型推断
18332105 RGD
involved in phospholipase C-activating adrenergic receptor signaling pathway IMP
IMP: 通过突变表型推断
19011682 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
19011682 RGD
involved in positive regulation of action potential IMP
IMP: 通过突变表型推断
17337632 RGD
involved in positive regulation of cardiac muscle contraction IMP
IMP: 通过突变表型推断
19011682 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
17588332 RGD
involved in positive regulation of heart rate IMP
IMP: 通过突变表型推断
22040923 RGD
involved in positive regulation of protein kinase C signaling IDA
IDA: 通过直接分析推断
18467629 RGD
involved in positive regulation of smooth muscle contraction IMP
IMP: 通过突变表型推断
19041301 RGD
involved in positive regulation of synaptic transmission, GABAergic IDA
IDA: 通过直接分析推断
14532911 RGD
involved in positive regulation of systemic arterial blood pressure IMP
IMP: 通过突变表型推断
22040923 RGD
involved in positive regulation of vasoconstriction IDA
IDA: 通过直接分析推断
15877108 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
19011682 RGD
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: 通过实验结果推断
12548707 RGD
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
12548707 RGD
involved in response to hormone IMP
IMP: 通过突变表型推断
11684150 RGD
involved in response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
17588332 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
22588352 RGD
located in T-tubule IDA
IDA: 通过直接分析推断
18467629 RGD
located in Z disc IDA
IDA: 通过直接分析推断
18467629 RGD
is active in dopaminergic synapse IDA
IDA: 通过直接分析推断
22588352 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
12548707 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
12548707 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
22588352 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
22588352 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

alpha-1A adrenergic receptor

adrenergic alpha 1c receptor

adrenergic receptor alpha 1c subtype

adrenergic receptor, alpha 1a

adrenergic receptor, alpha 1c

adrenergic, alpha-1A-, receptor

alpha-1A adrenoceptor

alpha-1A adrenoreceptor

alpha-1C adrenergic receptor

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00408 ADRA1A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS00410 ADRA1D Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21088 Adra1a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27606 Adra1a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Adra1a NCBI NCBI:148
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