1. Gene
  2. ADRA1A - adrenoceptor alpha 1A Gene

ADRA1A - adrenoceptor alpha 1A Gene


种属: Homo sapiens


基因 ID: 148 | 基因类型: protein coding


Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:26,748,150-26,867,379 (from NCBI)

This gene has 11 transcripts (splice variants), 203 orthologues and 18 paralogues. Biased expression in fat (RPKM 3.7), liver (RPKM 3.6) and 6 other tissues.


α-1-肾上腺素能受体 (alpha-1-ARs) 是 G 蛋白偶联受体超家族的成员。它们激活有丝分裂反应并调节许多细胞的生长和增殖。有 3 种 alpha-1-AR 亚型:alpha-1A、-1B 和 -1D,所有这些都通过 G 蛋白的 Gq/11 家族发出信号,不同的亚型显示不同的激活模式。该基因编码 alpha-1A-肾上腺素能受体。该基因的选择性剪接产生四种转录变体,它们编码四种具有不同 C 末端但具有相似配体结合特性的不同亚型。[RefSeq 提供,2008 年 7 月]

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]

ADRA1A 基因产物(7)

mRNA Protein Name
NM_000680.4 NP_000671.2 alpha-1A adrenergic receptor isoform 1
NM_001322502.1 NP_001309431.1 alpha-1A adrenergic receptor isoform 5
NM_001322503.1 NP_001309432.1 alpha-1A adrenergic receptor isoform 6
NM_001322504.1 NP_001309433.1 alpha-1A adrenergic receptor isoform 7
NM_033302.3 NP_150645.2 alpha-1A adrenergic receptor isoform 3
NM_033303.4 NP_150646.3 alpha-1A adrenergic receptor isoform 2
NM_033304.3 NP_150647.2 alpha-1A adrenergic receptor isoform 4

ADRA1A 蛋白结构


7tm_1: 7 transmembrane receptor (rhodopsin family) (43 - 326)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 466 a.a.
蛋白主名 其他名称

alpha-1A adrenergic receptor

G protein coupled receptor


疾病名称 别名

Calculus Of Ureter

Ureteric Stone

Ureteral Calculi

Ureteric Calculus

Stone In The Ureter

Ureter Calculi

Ureteral Calculus Or Stone


Ureterolithiasis Nos

Gilles De La Tourette Syndrome

Tourette Syndrome

Tourette Disorder



Gilles De La Tourette'S Syndrome

Motor-Verbal Tic Disorder

Guinon'S Disease

Psychogenic Tics

Tourette'S Syndrome

Chronic Motor And Vocal Tic Disorder


Tourette'S Disease

Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

Combined Vocal And Multiple Motor Tic Disorder

Tic De La Tourette



Priapism, Familial Idiopathic

Familial Idiopathic Priapism

Pathologic Erection

Painful Erection


Anxiety Disorder

Anxiety Disorders

Anxiety State


Anxiety Neurosis

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder


Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder



Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

Prostatic Hyperplasia, Benign

Benign Prostatic Hyperplasia


Prostatic Hyperplasia

Prostatic Hypertrophy

Benign Prostatic Hypertrophy

Prostatic Hyperplasia

Detrusor Sphincter Dyssynergia

Detrusor And Sphincter Dyssynergia

Situs Inversus

Situs Inversus Viscerum

Laterality Sequence

Complete Transposition




Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To


Dementia Praecox

Schizophrenia 1

Hypertension, Essential

Essential Hypertension


High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension


Hypertension, Salt-Sensitive Essential, Susceptibility To


Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5


Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Rattus norvegicus ADRA1A RGD RGD:2055
Mus musculus ADRA1A MGD MGI:104773
Macaca mulatta ADRA1A VGNC VGNC:69721
Felis catus ADRA1A VGNC VGNC:59654
Canis familiaris ADRA1A VGNC VGNC:37672
Bos taurus ADRA1A VGNC VGNC:25693