2. Gene
  3. Atp2a2 - ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Gene

Atp2a2 - ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Serca2; SercaII

基因 ID: 29693 | 基因类型: protein coding

关于 Atp2a2

功能概要

Enables several functions, including ATP binding activity; P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential; and lutropin-choriogonadotropic hormone receptor binding activity. Involved in several processes, including calcium ion transport; regulation of cardiac muscle cell membrane potential; and regulation of cardiac muscle contraction. Located in several cellular components, including apical ectoplasmic specialization; perinuclear region of cytoplasm; and sarcoplasmic reticulum. Is extrinsic component of cytoplasmic side of plasma membrane. Part of protein-containing complex. Used to study abdominal obesity-metabolic syndrome 1; congestive heart failure; and type 2 diabetes mellitus. Biomarker of euthyroid sick syndrome; heart disease; hypothyroidism; pulmonary hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). [provided by Alliance of Genome Resources, Apr 2022]

Atp2a2 基因产物(2)

mRNA Protein Name
NM_001110139.2 NP_001103609.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a
NM_001110823.2 NP_001104293.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
12409282 RGD
enables P-type calcium transporter activity IDA
IDA: 通过直接分析推断
9851937 RGD
enables calcium ion binding IDA
IDA: 通过直接分析推断
12409282 RGD
enables lutropin-choriogonadotropic hormone receptor binding IPI
IPI: 通过物理相互作用推断
17588601 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9295312 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcium ion import into sarcoplasmic reticulum IDA
IDA: 通过直接分析推断
9851937 RGD
involved in calcium ion transmembrane transport IDA
IDA: 通过直接分析推断
9851937 RGD
involved in calcium ion transport IDA
IDA: 通过直接分析推断
11595740 RGD
involved in cellular response to heat IEP
IEP: 通过表达模式推断
10748035 RGD
involved in regulation of cardiac muscle cell action potential involved in regulation of contraction IDA
IDA: 通过直接分析推断
9851937 RGD
involved in regulation of cardiac muscle cell membrane potential IDA
IDA: 通过直接分析推断
9851937 RGD
involved in regulation of cardiac muscle contraction by calcium ion signaling IDA
IDA: 通过直接分析推断
9851937 RGD
involved in relaxation of cardiac muscle IDA
IDA: 通过直接分析推断
9851937 RGD
involved in relaxation of skeletal muscle IEP
IEP: 通过表达模式推断
21993782 RGD
involved in response to endoplasmic reticulum stress IEP
IEP: 通过表达模式推断
10748035 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
25712896 RGD
involved in response to peptide hormone IDA
IDA: 通过直接分析推断
9295312 RGD
involved in sarcoplasmic reticulum calcium ion transport IDA
IDA: 通过直接分析推断
21300842 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical ectoplasmic specialization IDA
IDA: 通过直接分析推断
28486663 RGD
located in extrinsic component of cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
20177054 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
20177054 RGD
located in plasma membrane bounded cell projection IDA
IDA: 通过直接分析推断
28486663 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
17901878 RGD
located in sarcoplasmic reticulum IDA
IDA: 通过直接分析推断
8447366 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sarcoplasmic/endoplasmic reticulum calcium ATPase 2

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

ATPase, Ca++ transporting, slow twitch 2

SR Ca(2+)-ATPase 2

calcium pump 2

endoplasmic reticulum class 1/2 Ca(2+) ATPase

sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2

Atp2a2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Atp2a2 P11507 Tlr9 Mus musculus Q9EQU3
Anti Bait CoIP
24610369
种属间
Atp2a2 P11507 Tlr9 Mus musculus Q9EQU3
Imaging
24610369
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-15718A Istaroxime hydrochloride 99.32% Phase 2
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-131760 2'-NH2-ATP / 否
HY-RS01192 ATP2A2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01195 ATP2B2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01199 ATP2C2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17846 Atp2a2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24314 Atp2a2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Atp2a2 NCBI NCBI:488
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