2. Gene
  3. TIMM22 - translocase of inner mitochondrial membrane 22 Gene

TIMM22 - translocase of inner mitochondrial membrane 22 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：线粒体内膜转位酶 22

种属: Homo sapiens

同用名: TEX4; TIM22; COXPD43

基因 ID: 29928 | 基因类型: protein coding

关于 TIMM22

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:997,129-1,003,671 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 208 orthologues and is associated with 1 phenotype. Ubiquitous expression in heart (RPKM 10.4), placenta (RPKM 10.3) and 25 other tissues.

功能概要

多通道跨膜蛋白被带入线粒体并通过 TIM22 复合物插入线粒体内膜。该复合物有六个亚基，是一种双孔转位酶。该基因编码的蛋白质是 TIM22 的一个亚基，代表电压激活和信号门控通道。[RefSeq 提供，2016 年 7 月]

Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The protein encoded by this gene is a subunit of TIM22 and represents the voltage-activated and signal-gated channel. [provided by RefSeq, Jul 2016]

TIMM22 基因产物(1)

mRNA Protein Name
NM_013337.4 NP_037469.2 mitochondrial import inner membrane translocase subunit Tim22
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
27718247 GOA
enables protein transporter activity IMP
IMP: 通过突变表型推断
27554484 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein insertion into mitochondrial inner membrane IDA
IDA: 通过直接分析推断
28712724 GOA
involved in protein insertion into mitochondrial inner membrane IMP
IMP: 通过突变表型推断
27554484 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of TIM22 mitochondrial import inner membrane insertion complex IDA
IDA: 通过直接分析推断
27718247 GOA
part of TIM22 mitochondrial import inner membrane insertion complex IPI
IPI: 通过物理相互作用推断
32901109 GOA
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
32901109 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TIMM22 蛋白结构

Tim17

Tim17: Tim17/Tim22/Tim23/Pmp24 family (68 - 193)

  • 0
  • 100
  • 194 a.a.
蛋白主名 其他名称

mitochondrial import inner membrane translocase subunit Tim22

testis-expressed protein 4

TIMM22 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TIMM22 Q9Y584 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
TIMM22 Q9Y584 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
TIMM22 Q9Y584 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
种属内
TIMM22 Q9Y584 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
种属内
TIMM22 Q9Y584 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
种属内
TIMM22 Q9Y584 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

TIMM22 抗体

目录号 产品名 应用 反应物种
HY-P87106 TIMM22 Antibody (YA6799) WB, IHC-P, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Combined Oxidative Phosphorylation Deficiency 43

COXPD43
Combined Oxidative Phosphorylation Deficiency 18

Growth And Developmental Delay-Hypotonia-Vision Impairment-Lactic Acidosis Syndrome

COXPD18

Combined Oxidative Phosphorylation Deficiency, Type 18
Omodysplasia 2

OMOD2

Omodysplasia, Autosomal Dominant

Autosomal Dominant Omodysplasia

Omodysplasia Type 2

Omodysplasia, Type 2
Noonan Syndrome-Like Disorder With Loose Anagen Hair 2

NSLH2
Sengers Syndrome

Mitochondrial Dna Depletion Syndrome 10

Cardiomyopathy And Cataract

Cataract And Cardiomyopathy

MTDPS10

Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome

Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10

Senger Syndrome
Omodysplasia 1

OMOD1

Autosomal Recessive Omodysplasia

Omodysplasia Autosomal Recessive

Omodysplasia Generalized Form

Omodysplasia Type 1

Omodysplasia, Generalized Form

Omodysplasia, Autosomal Recessive

Micromelic Dysplasia, Congenital, With Dislocation Of Radius

Micromelic Dysplasia Congenita With Dislocation Of Radius

Micromelic Dysplasia-Dislocation Of Radius Syndrome

Micromelic Dysplasia Congenital With Dislocation Of Radius

Omodysplasia, Type 1
Omodysplasia

Omodysplasia Type 1

Omodysplasia 2
Myopathy

Muscular Diseases

Myopathies
Gastroesophageal Reflux

Gastroesophageal Reflux Disease

Gerd

GER

Gastroesophageal Reflux, Pediatric

Acid Reflux

Gastresophageal Reflux

Gastro-Esophageal Reflux

Gerd - Gastro-Esophageal Reflux Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14530 TIMM22 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TIMM22 VGNC VGNC:49575
Mus musculus TIMM22 MGD MGI:1929742
Canis familiaris TIMM22 VGNC VGNC:49097
Rattus norvegicus TIMM22 RGD RGD:68406
Felis catus TIMM22 VGNC VGNC:99557
Macaca mulatta TIMM22 VGNC VGNC:99299
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