2. Gene
  3. Hcn4 - hyperpolarization-activated, cyclic nucleotide-gated K+ 4 Gene

Hcn4 - hyperpolarization-activated, cyclic nucleotide-gated K+ 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Hcn3; Bcng3

基因 ID: 330953 | 基因类型: protein coding

关于 Hcn4

功能概要

Enables intracellular cAMP-activated cation channel activity. Acts upstream of or within cation transport; in utero embryonic development; and regulation of heart contraction. Located in axon. Is expressed in eye; future brain; heart; septum transversum; and venous system. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; idiopathic generalized epilepsy; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated Potassium Channel 4). [provided by Alliance of Genome Resources, Apr 2022]

Hcn4 基因产物(1)

mRNA Protein Name
NM_001081192.3 NP_001074661.1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables intracellularly cAMP-activated cation channel activity IMP
IMP: 通过突变表型推断
14657344 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15564593 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
14657344 MGI
acts upstream of or within monoatomic cation transport IMP
IMP: 通过突变表型推断
14657344 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: 通过突变表型推断
14657344 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
23172916 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

brain cyclic nucleotide-gated channel 3

hyperpolarization-activated, cyclic nucleotide-gated K+ 3

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-18940 Cilobradine / Phase 2
Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13422 Zatebradine hydrochloride Antagonist 99.87% 否
HY-13422A Zatebradine Antagonist 99.27% 否
HY-160505 RO-275 Inhibitor ≥99.0% 否
HY-119102 BPU-11 98.08% 否
HY-RS06049 HCN4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19140 Hcn3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20286 Hcn4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26794 Hcn4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hcn4 NCBI NCBI:10021
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