2. Gene
  3. MN1 - MN1 proto-oncogene, transcriptional regulator Gene

MN1 - MN1 proto-oncogene, transcriptional regulator Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MN1 原癌基因，转录调节因子

种属: Homo sapiens

同用名: MGCR; MGCR1; CEBALID; MGCR1-PEN; dJ353E16.2

基因 ID: 4330 | 基因类型: protein coding

关于 MN1

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:27,748,277-27,801,756 (from NCBI)

This gene has 4 transcripts (splice variants), 184 orthologues and is associated with 83 phenotypes. Ubiquitous expression in brain (RPKM 2.3), esophagus (RPKM 2.2) and 21 other tissues.

功能概要

脑膜瘤 1 (MN1) 包含两组 CAG 重复序列。它被脑膜瘤中的平衡易位 (4;22) 破坏，其失活可能有助于脑膜瘤 32 的发病机制。[RefSeq 提供，2008 年 7 月]

Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]

MN1 基因产物(1)

mRNA Protein Name
NM_002430.3 NP_002421.3 transcriptional activator MN1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
31839203 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of osteoblast proliferation IDA
IDA: 通过直接分析推断
15890672 GOA
involved in positive regulation of vitamin D receptor signaling pathway IDA
IDA: 通过直接分析推断
15890672 GOA
involved in regulation of cell cycle G1/S phase transition IDA
IDA: 通过直接分析推断
15890672 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
31839203 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transcriptional activator MN1

meningioma (disrupted in balanced translocation) 1

关联疾病

疾病名称 别名
Cebalid Syndrome

Mn1 C-Terminal Truncation Syndrome

CEBALID

Craniofacial Defects, Dysmorphic Ears, Structural Brain Abnormalities, Expressive Language Delay, And Impaired Intellectual Development

Mctt

Mctt Syndrome

Mn1 C-Terminal Truncation Syndrome
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
Rhombencephalosynapsis
Chordoma

CHDM

Notochordoma

Notochordal Sarcoma

Chordoma, Susceptibility To

Chordocarcinoma

Chordoepithelioma
Astroblastoma

Cerebral Astroblastoma
Cns Neuroblastoma With Foxr2 Activation

Central Nervous System Neuroblastoma With Foxr2 Activation

Cns Nb-Foxr2

Cns Neuroblastoma, Foxr2-Activated
Central Nervous System Neuroblastoma
Astroblastoma, Mn1-Altered

Cns High-Grade Neuroepithelial Tumors With Mn1 Alteration
Central Nervous System Germ Cell Tumor

Central Nervous System Germ Cell Tumour

Germ Cell Tumor Of The Cns

Germ Cell Tumour Of The Cns
Anaplastic Pleomorphic Xanthoastrocytoma
Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Supratentorial Ependymoma
High Grade Ependymoma

Ependymal Neoplasm

Ependymal Tumors

Malignant Ependymoma

Ependymal Tumor

Anaplastic Ependymoma

Experimental Organism Malignant Ependymoma

Ependymoma Of Brain
Childhood Infratentorial Ependymoma

Pediatric Infratentorial Ependymoma
Anaplastic Ependymoma

Ependymoma, Anaplastic

Undifferentiated Ependymoma
Rela Fusion-Positive Ependymoma

Supratentorial C11orf95-Rela Fused Ependymoma

C11orf95 Fusion-Positive Supratentorial Ependymoma
Chondroid Lipoma
Pleomorphic Xanthoastrocytoma

Pxa

Pleomorphic Xantho-Astrocytoma
Polymicrogyria

Pmg
Cerebral Ventricle Cancer

Cerebral Ventricle Neoplasms

Cerebral Ventricle Neoplasm

Intraventricular Tumor Of Brain
Supratentorial Cancer

Supratentorial Neoplasms

Brain Neoplasm, Supratentorial

Malignant Supratentorial Tumor

Cancer, Supratentorial
Cerebrum Cancer

Cerebral Cancer

Neoplasm Of Cerebrum

Tumor Of Cerebrum

Malignant Neoplasm Of Cerebrum
Myxopapillary Ependymoma

Ependymoma Myxopapillary
Large Congenital Melanocytic Nevus

Giant Pigmented Hairy Nevus

Giant Congenital Melanocytic Nevus

Gmn

Congenital Pigmented Nevus

Lcmn

Gphn

Giant Congenital Nevus

Bathing Trunk Nevus

Congenital Giant Pigmented Nevus

Congenital Hairy Nevus

Giant Hairy Nevus

Giant Pigmented Nevus

Congenital Giant Pigmented Nevus Of Skin

Congenital Melanocytic Nevus Syndrome

Giant Congenital Melanocytic Nevi

Giant Congenital Pigmented Nevus

Melanocytic Nevus Syndrome, Congenital
Pineal Gland Cancer

Tumor Of The Pineal Region

Malignant Pineal Region Tumor

Malignant Tumor Of Pineal Gland

Neoplasm Of Pineal Gland

Neoplasm Of The Pineal Region

Pineal Body Neoplasm

Pineocytic Tumor

Malignant Neoplasm Of Pineal Gland

Pineal Gland Neoplasm

Pineocytoma
Tanycytic Ependymoma
Chordoid Glioma

Chordoid Glioma Of The Third Ventricle
Embryonal Tumor With Multilayered Rosettes, C19mc-Altered

Ependymoblastoma
Gaucher Disease, Type Ii

GD2

Gd Ii

Gaucher Disease, Acute Neuronopathic Type

Gaucher Disease Type 2

Gaucher Disease Type Ii

Gaucher'S Disease Type Ii

Infantile Cerebral Gaucher Disease

Acute Neuronopathic Gaucher Disease

Gd 2

Gaucher Disease, Infantile Cerebral

Gaucher Disease 2

Type 2 Gaucher Disease

Gaucher Disease, Type 2
Solitary Fibrous Tumor/Hemangiopericytoma

Sft/Hpc
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99584 Suvizumab Inhibitor ≥99.0% Phase 1
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08565 MN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19865 Mn1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26364 Mn1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-19378 MIV-150 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta MN1 VGNC VGNC:107802
Rattus norvegicus MN1 RGD RGD:1565571
Bos taurus MN1 VGNC VGNC:31536
Canis familiaris MN1 VGNC VGNC:52951
Mus musculus MN1 MGD MGI:1261813
Others MN1 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z