PPP1R12B - protein phosphatase 1 regulatory subunit 12B Gene

中文名称：蛋白磷酸酶 1 调节亚基 12B

种属: Homo sapiens

同用名: MYPT2; PP1bp55

关于 PPP1R12B

功能概要

肌球蛋白磷酸酶是一种蛋白质复合物，由三个亚基组成：催化亚基 (PP1c-delta、蛋白磷酸酶 1、催化亚基 delta) 、大调节亚基 (MYPT、肌球蛋白磷酸酶靶标) 和小调节亚基 (sm-M20) 。已分离出 MYPT 的两种亚型——MYPT1 和 MYPT2，第一种广泛表达，第二种可能特异于心脏、骨骼肌和大脑。每种 MYPT 亚型都具有结合 PP1c-delta 和增加磷酸酶活性的功能。该基因座编码 MYTP2 和 M20。已经鉴定出编码不同亚型的选择性剪接转录物变体。相关假基因已在 Y 染色体上定义。[RefSeq 提供，2011 年 10 月]

Myosin Phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein Phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin Phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase Phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]