1. Gene
  2. NTRK3 - neurotrophic receptor tyrosine kinase 3 Gene

NTRK3 - neurotrophic receptor tyrosine kinase 3 Gene

中文名称:神经营养受体酪氨酸激酶 3

种属: Homo sapiens

同用名: TRKC; GP145-TrkC; gp145(trkC)

基因 ID: 4916 | 基因类型: protein coding

关于 NTRK3

Cytogenetic location: 15q25.3 Genomic coordinates (GRCh38): 15:87,859,751-88,256,739 (from NCBI)

This gene has 19 transcripts (splice variants), 271 orthologues, 53 paralogues and is associated with 138 phenotypes. Biased expression in brain (RPKM 2.8), fat (RPKM 1.2) and 13 other tissues.

功能概要

该基因编码神经营养性酪氨酸受体激酶 (NTRK) 家族的成员。这种激酶是一种膜结合受体,在神经营养蛋白结合后,磷酸化自身和 MAPK 通路的成员。通过这种激酶发出的信号导致细胞分化,并可能在感知身体位置的本体感受神经元的发育中发挥作用。该基因的突变与髓母细胞瘤、分泌性乳腺癌和其他癌症有关。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供,2011 年 7 月]

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

NTRK3 基因产物(34)

mRNA Protein Name
NM_001012338.3 NP_001012338.1 NT-3 growth factor receptor isoform a precursor
XM_017022252.3 XP_016877741.1 NT-3 growth factor receptor isoform X17
XM_024449934.2 XP_024305702.1 NT-3 growth factor receptor isoform X6
NM_001375811.1 NP_001362740.1 NT-3 growth factor receptor isoform b precursor
XM_017022245.3 XP_016877734.1 NT-3 growth factor receptor isoform X4
NM_001320134.1 NP_001307063.1 NT-3 growth factor receptor isoform e precursor
XM_017022251.3 XP_016877740.1 NT-3 growth factor receptor isoform X16
NM_001320135.2 NP_001307064.1 NT-3 growth factor receptor isoform f
XM_017022254.3 XP_016877743.1 NT-3 growth factor receptor isoform X18
XM_017022241.2 XP_016877730.1 NT-3 growth factor receptor isoform X2
XM_017022240.2 XP_016877729.1 NT-3 growth factor receptor isoform X1
XM_006720549.5 XP_006720612.1 NT-3 growth factor receptor isoform X11
XR_002957645.2
XM_017022242.3 XP_016877731.1 NT-3 growth factor receptor isoform X3
NM_001375812.1 NP_001362741.1 NT-3 growth factor receptor isoform d precursor
XM_047432602.1 XP_047288558.1 NT-3 growth factor receptor isoform X7
XR_001751292.3
XM_024449935.2 XP_024305703.1 NT-3 growth factor receptor isoform X9
NM_001243101.2 NP_001230030.1 NT-3 growth factor receptor isoform d precursor
XM_017022250.3 XP_016877739.1 NT-3 growth factor receptor isoform X13
NM_001375813.1 NP_001362742.1 NT-3 growth factor receptor isoform c precursor
XM_006720545.5 XP_006720608.1 NT-3 growth factor receptor isoform X5
NM_001007156.3 NP_001007157.1 NT-3 growth factor receptor isoform c precursor
XM_006720550.5 XP_006720613.1 NT-3 growth factor receptor isoform X12
XM_011521638.4 XP_011519940.1 NT-3 growth factor receptor isoform X14
NM_002530.4 NP_002521.2 NT-3 growth factor receptor isoform b precursor
XM_047432604.1 XP_047288560.1 NT-3 growth factor receptor isoform X15
XR_001751293.3
NM_001375814.1 NP_001362743.1 NT-3 growth factor receptor isoform g precursor
XM_017022244.3 XP_016877733.1 NT-3 growth factor receptor isoform X4
XM_006720548.5 XP_006720611.1 NT-3 growth factor receptor isoform X10
XM_047432603.1 XP_047288559.1 NT-3 growth factor receptor isoform X8
NM_001375810.1 NP_001362739.1 NT-3 growth factor receptor isoform a precursor
XM_017022243.2 XP_016877732.1 NT-3 growth factor receptor isoform X4

NTRK3 蛋白结构

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (31 - 56)

LRR_8

LRR_8: Leucine rich repeat (104 - 160)

I-set

I-set: Immunoglobulin I-set domain (210 - 301)

I-set

I-set: Immunoglobulin I-set domain (323 - 391)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (539 - 824)

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  • 839 a.a.
蛋白主名 其他名称

NT-3 growth factor receptor

ETS related protein-neurotrophic receptor tyrosine kinase fusion protein

ETV6-NTRK3 fusion

neurotrophic tyrosine kinase, receptor, type 3

tyrosine kinase receptor C

重组 NTRK3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73464 TrkC Protein, Human (HEK293, His-Fc) Q16288 (M1-D428) ≥95%
HY-P73465 TrkC Protein, Human (HEK293, His) Q16288 (M1-D428) ≥95%

关联疾病

疾病名称 别名
Kidney Rhabdoid Cancer

Rhabdoid Tumor Of The Kidney

Kidney Rhabdoid Tumor

Renal Rhabdoid Tumor

Spindle Cell Sarcoma

Sarcoma

Sarcoma Spindle Cell

Sarcoma, Spindle Cell

Sarcoma - Category

Tonsil Cancer

Tonsillar Neoplasms

Malignant Neoplasm Of Faucial Tonsil

Malignant Neoplasm Of Palatine Tonsil

Malignant Neoplasm Of Tonsil, Faucial

Malignant Tonsillar Tumor

Malignant Tumor Of Tonsil

Tonsillar Carcinoma

Malignant Neoplasm Tonsil

Salivary Gland Adenoid Cystic Carcinoma

Cylindroma

Gastrointestinal Stromal Tumor

GIST

Gastrointestinal Stromal Tumors

Gastrointestinal Stromal Sarcoma

Gastrointestinal Stromal Tumor, Familial

Gant

Gastrointestinal Stromal Tumour

Stromal Tumor Of Gastrointestinal Tract

Stromal Tumour Of Gastrointestinal Tract

Gastrointestinal Stromal Neoplasm

Paraganglioma And Gastric Stromal Sarcoma

Plexosarcoma

Childhood Fibrosarcoma

Pediatric Fibrosarcoma

Cellular Congenital Mesoblastic Nephroma
Glioma
Mastocytosis

Mast Cell Disease

Mast Cell Hyperplasia

Urticaria Pigmentosa

Malignant Mastocytoma

Malignant Mast Cell Tumours

Malignant Mastocytosis

Spitzoid Melanoma

Atypical Spitz Nevus

Mast-Cell Leukemia

Mast Cell Leukemia

Leukemia, Mast-Cell

Leukemia Mast Cell

Mast Cell Leukaemia Nos

Mast Cell Leukaemia Without Mention Of Remission

Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Congenital Megacolon

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

Hirschsprung'S Disease

Congenital Intestinal Aganglionosis

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon

Lipid-Rich Carcinoma
Pregnancy Adenoma

Lactating Adenoma

Acinar Cell Carcinoma

Acinic Cell Carcinoma

Acinic Cell Tumor

Carcinoma Acinar Cell

Carcinoma, Acinar Cell

Acinar Cell Tumor

Congenital Mesoblastic Nephroma

Nephroma, Mesoblastic

Mesoblastic Nephroma

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Ganglioneuroma
Mixed Lacrimal Gland Cancer

Carcinoma Ex Pleomorphic Adenoma Of Lacrimal Gland

Carcinoma Ex Pleomorphic Adenoma Of The Lacrimal Gland

Malignant Mixed Neoplasm Of Lacrimal Gland

Breast Secretory Carcinoma

Secretory Breast Carcinoma

Juvenile Breast Carcinoma

Juvenile Carcinoma Of The Breast

Juvenile Secretory Carcinoma Of Breast

Juvenile Breast Cancer

Sbc

Secretory Carcinoma Of The Breast

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Thyroid Gland Cancer

Thyroid Gland Carcinoma

Malignant Neoplasm Of Thyroid Gland

Malignant Tumour Of Thyroid Gland

Thyroid Neoplasm

Thyroid Neoplasms

Neoplasm Of Thyroid Gland

Thyroid Gland Neoplasm

Head And Neck Cancer, Thyroid

Neoplasm Of The Thyroid Gland

Cancer Of The Thyroid

Primary Malignant Neoplasm Of Thyroglossal Duct

Malignant Neoplasm Of Thyroglossal Duct

Primary Malignant Neoplasm Of Thyroid Gland

Thyroglossal Duct Cancer

Toxic Goitre Malignant Tumour

Cancerous Goitre

Congenital Fibrosarcoma

Infantile Fibrosarcoma

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia

Panic Disorder

Panic Anxiety Syndrome

Panic

Panic Disorder 1

Episodic Paroxysmal Anxiety Disorder

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Spiradenoma

Eccrine Spiradenoma

Benign Eccrine Spiradenoma

Eccrine Spiradenoma Of Skin

Es

Eccrine Spiradenoma, Benign

Kidney Fibrosarcoma

Fibrosarcoma Of The Kidney

Mammary Analogue Secretory Carcinoma
Mast Cell Neoplasm

Mastocytoma

Mast Cell Proliferative Disease

Mast Cell Tumor

Benign Mastocytoma

Constipation
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Kidney Clear Cell Sarcoma

Clear Cell Sarcoma Of Kidney

Childhood Kidney Clear Cell Sarcoma

Renal Clear Cell Sarcoma

Ccsk

Clear Cell Sarcoma Of The Kidney

Asperger Syndrome

Asperger Disorder

Breast Adenoid Cystic Carcinoma

Adenoid Cystic Breast Carcinoma

Adenoid Cystic Carcinoma Of Breast

Mammary Adenocystic Carcinoma

Fibrosarcoma

Neoplasms, Fibrous Tissue

Fibrocytic Tumor

Fibrosarcoma Of Soft Tissue

Fibrous Tissue Neoplasm

Parotid Gland Cancer

Cancer Of Parotid Gland

Parotid Neoplasms

Malignant Neoplasm Of The Parotid

Malignant Tumor Of Parotid Gland

Parotid Cancer

Parotid Neoplasm

Parotid Gland Carcinoma

Cancer Of Parotid

Malignant Tumour Of Parotid Gland

Parotid Duct Cancer

Parotid Ductal Cancer

Parotid Glandular Cancer

Primary Malignant Neoplasm Of Parotid Gland

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Brain Cancer

Malignant Neoplasm Of Brain

Adult Brain Tumor

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary

Nephroma

Benign Nephroma

Dermatofibrosarcoma Protuberans

DFSP

Dermatofibrosarcoma

Giant Cell Fibroblastoma

Metastatic Dermatofibrosarcoma Protuberans

Familial Dermatofibrosarcoma Protuberans

Darier-Ferrand Tumor

Darier-Hoffmann Tumor

Lipofibromatosis-Like Neural Tumor
Salivary Gland Carcinoma

Salivary Gland Cancer

Malignant Neoplasm Of Salivary Gland

Salivary Gland Neoplasms

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Infantile Myofibromatosis

Lipofibromatosis

Myofibromatosis

Pleomorphic Adenoma Carcinoma

Carcinoma Ex Pleomorphic Adenoma

Carcinoma In Pleomorphic Adenoma

Mucoepidermoid Carcinoma

Mec

Salivary Gland Mucoepidermoid Carcinoma

C3772

Carcinoma Mucoepidermoid

Carcinoma, Mucoepidermoid

Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Paraganglioma

Chemodectoma

Glomus Body Tumor

Paragangliomas

Carotid Body Paraganglioma

Extra-Adrenal Paraganglioma

Breast Juvenile Papillomatosis

Juvenile Papillomatosis Of The Breast

Thyroid Gland Follicular Carcinoma

Follicular Thyroid Carcinoma

Follicular Adenocarcinoma

Follicular Adenocarcinoma, Well Differentiated

Follicular Carcinoma

Thyroid Adenocarcinoma

Adenocarcinoma, Follicular

Adult Fibrosarcoma
Oligodendroglioma

Oligodendroglial Neoplasm

Oligodendroglial Tumor

Oligodendroglial Tumors

Well Differentiated Oligodendroglioma

Malignant Giant Cell Tumor Of The Tendon Sheath

Giant Cell Tumour Of Tendon Sheath, Malignant

Malignant Giant Cell Neoplasm Of The Tendon Sheath

Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma

Well-Differentiated Thyroid Carcinoma

Differentiated Thyroid Gland Carcinoma

Mesenchymal Cell Neoplasm

Benign Miscellaneous Mesenchymal Tumor

Mesenchymal Tumor

Mesenchymal Tumors

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Oropharynx Cancer

Oropharyngeal Cancer

Oropharyngeal Carcinoma

Malignant Neoplasm Of Oropharynx

Malignant Oropharyngeal Tumor

Malignant Tumor Of Oropharynx

Malignant Tumour Of Mesopharynx

Oropharyngeal Cancer, Adult

Cancer Of The Oropharynx

Salivary Gland Disease

Salivary Gland Disorders

Salivary Gland Diseases

Non-Neoplastic Salivary Gland Disease

Non-Neoplastic Salivary Gland Disorder

Disorder Of Salivary Gland

Lesion Of Salivary Gland Nos

Epithelial-Myoepithelial Carcinoma

Clear Cell Adenoma

Adenomyo-Epithelioma

Clear Cell Carcinoma

Emc

Epithelial Myoepithelial Carcinoma

Glycogen-Rich Adenocarcinoma

Glycogen-Rich Adenoma

Monomorphic Clear Cell Tumor

Tubular Solid Adenoma

Adenocarcinoma, Clear Cell

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NTRK3 VGNC VGNC:75542
Canis familiaris NTRK3 VGNC VGNC:49932
Bos taurus NTRK3 VGNC VGNC:106849
Felis catus NTRK3 VGNC VGNC:68580
Rattus norvegicus NTRK3 RGD RGD:3214
Mus musculus NTRK3 MGD MGI:97385
Others NTRK3 NCBI