1. Gene
  2. ATP5F1B - ATP synthase F1 subunit beta Gene

ATP5F1B - ATP synthase F1 subunit beta Gene

中文名称:ATP 合酶 F1 亚基β

种属: Homo sapiens

同用名: ATP5B; ATPMB; ATPSB; HUMOP2; HEL-S-271

基因 ID: 506 | 基因类型: protein coding

关于 ATP5F1B

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,638,175-56,645,984 (from NCBI)

This gene has 11 transcripts (splice variants), 259 orthologues and 4 paralogues. Ubiquitous expression in heart (RPKM 713.8), kidney (RPKM 376.0) and 25 other tissues.

功能概要

该基因编码线粒体 ATP 合酶的一个亚基。线粒体 ATP 合酶催化 ATP 合成,利用氧化磷酸化过程中跨内膜的质子电化学梯度。 ATP 合酶由两个连接的多亚基复合物组成:可溶性催化核心 F1 和跨膜成分 Fo,构成质子通道。线粒体 ATP 合酶的催化部分由 5 个不同的亚基 (alpha、beta、gamma、delta 和 epsilon) 组成,其化学计量为 3 个 alpha、3 个 beta 和其他 3 个的单一代表。质子通道由三个组成主要亚基 (a、b、c) 。该基因编码催化核心的β亚基。[RefSeq 提供,2008 年 7 月]

This gene encodes a subunit of mitochondrial ATP Synthase. Mitochondrial ATP Synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP Synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP Synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]

ATP5F1B 基因产物(1)

mRNA Protein Name
NM_001686.4 NP_001677.2 ATP synthase subunit beta, mitochondrial precursor

ATP5F1B 蛋白结构

ATP-synt_ab_N

ATP-synt_ab_N: ATP synthase alpha/beta family, beta-barrel domain (63 - 129)

ATP-synt_ab

ATP-synt_ab: ATP synthase alpha/beta family, nucleotide-binding domain (185 - 405)

ATP-synt_ab_C

ATP-synt_ab_C: ATP synthase alpha/beta chain, C terminal domain (418 - 521)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 529 a.a.
蛋白主名 其他名称

ATP synthase subunit beta, mitochondrial

ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide

重组 ATP5F1B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71716 ATP5F1B Protein, Human (P.pastoris, His) P06576 (48A-529S) ≥95%

关联疾病

疾病名称 别名
Hydronephrosis

Stricture Of Ureteropelvic Junction With Hydronephrosis

Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ATP5F1B MGD MGI:107801
Rattus norvegicus ATP5F1B RGD RGD:621368
Bos taurus ATP5F1B VGNC VGNC:26300
Felis catus ATP5F1B VGNC VGNC:83505
Others ATP5F1B NCBI