1. Gene
  2. ATP5F1B - ATP synthase F1 subunit beta Gene

ATP5F1B - ATP synthase F1 subunit beta Gene

中文名称:ATP 合酶 F1 亚基β

种属: Homo sapiens

同用名: ATP5B; ATPMB; ATPSB; HUMOP2; HEL-S-271

基因 ID: 506 | 基因类型: protein coding

关于 ATP5F1B

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,638,175-56,645,984 (from NCBI)

This gene has 11 transcripts (splice variants), 259 orthologues and 4 paralogues. Ubiquitous expression in heart (RPKM 713.8), kidney (RPKM 376.0) and 25 other tissues.

功能概要

该基因编码线粒体 ATP 合酶的一个亚基。线粒体 ATP 合酶催化 ATP 合成,利用氧化磷酸化过程中跨内膜的质子电化学梯度。 ATP 合酶由两个连接的多亚基复合物组成:可溶性催化核心 F1 和跨膜成分 Fo,构成质子通道。线粒体 ATP 合酶的催化部分由 5 个不同的亚基 (alpha、beta、gamma、delta 和 epsilon) 组成,其化学计量为 3 个 alpha、3 个 beta 和其他 3 个的单一代表。质子通道由三个组成主要亚基 (a、b、c) 。该基因编码催化核心的β亚基。[RefSeq 提供,2008 年 7 月]

This gene encodes a subunit of mitochondrial ATP Synthase. Mitochondrial ATP Synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during Oxidative Phosphorylation. ATP Synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP Synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the Other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]

ATP5F1B 基因产物(1)

mRNA Protein Name
NM_001686.4 NP_001677.2 ATP synthase subunit beta, mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables MHC class I protein binding IDA
IDA: 通过直接分析推断
17643490 GOA
enables angiostatin binding IPI
IPI: 通过物理相互作用推断
21106936 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10077593 GOA
contributes to proton-transporting ATP synthase activity, rotational mechanism IDA
IDA: 通过直接分析推断
12110673 GOA
enables proton-transporting ATP synthase activity, rotational mechanism IMP
IMP: 通过突变表型推断
21106936 GOA
enables proton-transporting ATPase activity, rotational mechanism IMP
IMP: 通过突变表型推断
17510399 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ATP biosynthetic process IMP
IMP: 通过突变表型推断
17510399 GOA
involved in angiogenesis IMP
IMP: 通过突变表型推断
17510399 GOA
involved in positive regulation of blood vessel endothelial cell migration IGI
IGI: 通过遗传相互作用推断
21106936 GOA
involved in proton motive force-driven mitochondrial ATP synthesis IDA
IDA: 通过直接分析推断
12110673 GOA
involved in proton transmembrane transport IMP
IMP: 通过突变表型推断
17510399 GOA
involved in regulation of intracellular pH IMP
IMP: 通过突变表型推断
17510399 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
17510399 GOA
located in membrane IDA
IDA: 通过直接分析推断
21106936 GOA
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
8006588 GOA
located in mitochondrial nucleoid IDA
IDA: 通过直接分析推断
18063578 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
2870059 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
10077593 GOA
part of proton-transporting ATP synthase complex IDA
IDA: 通过直接分析推断
12110673 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ATP5F1B 蛋白结构

ATP-synt_ab_N

ATP-synt_ab_N: ATP synthase alpha/beta family, beta-barrel domain (63 - 129)

ATP-synt_ab

ATP-synt_ab: ATP synthase alpha/beta family, nucleotide-binding domain (185 - 405)

ATP-synt_ab_C

ATP-synt_ab_C: ATP synthase alpha/beta chain, C terminal domain (418 - 521)

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  • 529 a.a.
蛋白主名 其他名称

ATP synthase subunit beta, mitochondrial

ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide

ATP5F1B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ATP5F1B P06576 ATPAF1 Homo sapiens Q5TC12 28514442
种属内
ATP5F1B P06576 ATPAF1 Homo sapiens Q5TC12 33961781
种属内
ATP5F1B P06576 ATPAF2 Homo sapiens Q8N5M1 32296183
种属内
ATP5F1B P06576 LNX2 Homo sapiens Q8N448 31515488
种属内
ATP5F1B P06576 LNX2 Homo sapiens Q8N448 29892012
种属内
ATP5F1B P06576 YWHAZ Homo sapiens P63104 15161933
种属内
ATP5F1B P06576 ATP5F1A Homo sapiens P25705 33961781
种属内
ATP5F1B P06576 ATP5F1A Homo sapiens P25705 28514442
种属内
ATP5F1B P06576 ATP5F1A Homo sapiens P25705 30021884
种属内
ATP5F1B P06576 BYSL Homo sapiens Q13895 32296183
种属内
ATP5F1B P06576 ATP5IF1 Homo sapiens Q9UII2 28514442
种属内
ATP5F1B P06576 ATP5PD Homo sapiens O75947 33961781
种属内
ATP5F1B P06576 ATP5PD Homo sapiens O75947 30021884
种属内
ATP5F1B P06576 ATXN1 Homo sapiens P54253 32814053
种属内
ATP5F1B P06576 ATXN1 Homo sapiens P54253 32814053
种属内
ATP5F1B P06576 ATXN1 Homo sapiens P54253 32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ATP5F1B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71716 ATP5F1B Protein, Human (P.pastoris, His) P06576 (A48-S529) ≥95%

ATP5F1B 抗体

目录号 产品名 应用 反应物种
HY-P82469 ATPB Antibody (YA2214) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat, Monkey
HY-P86505 ATPB Antibody (YA6197) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

关联疾病

疾病名称 别名
Hydronephrosis

Stricture Of Ureteropelvic Junction With Hydronephrosis

Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ATP5F1B MGD MGI:107801
Rattus norvegicus ATP5F1B RGD RGD:621368
Bos taurus ATP5F1B VGNC VGNC:26300
Felis catus ATP5F1B VGNC VGNC:83505
Others ATP5F1B NCBI