2. Gene
  3. Stk39 - serine/threonine kinase 39 Gene

Stk39 - serine/threonine kinase 39 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: DCHT; Rnl5; SPAK; RF005

基因 ID: 53416 | 基因类型: protein coding

关于 Stk39

功能概要

Enables protein serine/threonine kinase activity. Involved in several processes, including cellular hypotonic response; negative regulation of transport; and protein phosphorylation. Acts upstream of or within several processes, including negative regulation of potassium ion transmembrane transport; negative regulation of protein phosphorylation; and regulation of inflammatory response. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in brain and metanephros. Used to study Gitelman syndrome and pseudohypoaldosteronism. Orthologous to human STK39 (serine/threonine kinase 39). [provided by Alliance of Genome Resources, Apr 2022]

Stk39 基因产物(5)

mRNA Protein Name
NM_001412544.1 NP_001399473.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform 2
NM_001412545.1 NP_001399474.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform 3
NM_001412546.1 NP_001399475.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform 4
NM_001412547.1 NP_001399476.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform 5
NM_016866.3 NP_058562.1 STE20/SPS1-related proline-alanine-rich protein kinase isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables kinase activity IMP
IMP: 通过突变表型推断
16530727 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12386165 MGI
enables protein serine/threonine kinase activity IGI
IGI: 通过遗传相互作用推断
24393035 MGI
enables protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
27782176 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular hypotonic response IGI
IGI: 通过遗传相互作用推断
24393035 MGI
involved in cellular response to potassium ion IDA
IDA: 通过直接分析推断
31736353 MGI
involved in inflammatory response IMP
IMP: 通过突变表型推断
31786261 MGI
involved in intracellular chloride ion homeostasis IGI
IGI: 通过遗传相互作用推断
29459793 MGI
involved in intracellular signal transduction IGI
IGI: 通过遗传相互作用推断
24393035 MGI
involved in macrophage activation IMP
IMP: 通过突变表型推断
31786261 MGI
involved in maintenance of lens transparency IMP
IMP: 通过突变表型推断
25515571 MGI
acts upstream of or within monoatomic ion homeostasis IMP
IMP: 通过突变表型推断
21907141 MGI
involved in negative regulation of pancreatic juice secretion IMP
IMP: 通过突变表型推断
21317537 MGI
involved in negative regulation of potassium ion transmembrane transport IGI
IGI: 通过遗传相互作用推断
24393035 MGI
involved in negative regulation of potassium ion transmembrane transporter activity IGI
IGI: 通过遗传相互作用推断
24393035 MGI
involved in peptidyl-threonine phosphorylation IGI
IGI: 通过遗传相互作用推断
24393035 MGI
involved in peptidyl-threonine phosphorylation IMP
IMP: 通过突变表型推断
27782176 MGI
involved in protein autophosphorylation IMP
IMP: 通过突变表型推断
16530727 MGI
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
16530727 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: 通过突变表型推断
21907141 MGI
acts upstream of or within regulation of inflammatory response IDA
IDA: 通过直接分析推断
21705622 MGI
involved in response to aldosterone IGI
IGI: 通过遗传相互作用推断
24039833 MGI
involved in response to dietary excess IMP
IMP: 通过突变表型推断
24761002 MGI
involved in sodium ion transmembrane transport IMP
IMP: 通过突变表型推断
31736353 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in apical plasma membrane IDA
IDA: 通过直接分析推断
31736353 MGI
located in apical plasma membrane IDA
IDA: 通过直接分析推断
12386165 MGI
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
12386165 MGI
is active in cell body IDA
IDA: 通过直接分析推断
31736353 MGI
located in membrane IDA
IDA: 通过直接分析推断
12386165 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

STE20/SPS1-related proline-alanine-rich protein kinase

Ste-20 related kinase

kidney-specific SPAK

serine/threonine kinase 39, STE20/SPS1 homolog

serine/threonine-protein kinase 39

ste-20-related kinase

Stk39 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Stk39 Q9Z1W9 Slc12a6 Mus musculus Q924N4-1
Y2H
12386165
种属内
Stk39 Q9Z1W9 Slc12a2 Mus musculus P55012
Anti Bait CoIP
14563843
种属内
Stk39 Q9Z1W9 Slc12a2 Mus musculus P55012
Y2H
12386165
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13940 STK39 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21058 Stk39 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27575 Stk39 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Stk39 NCBI NCBI:27347
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