PDPR - pyruvate dehydrogenase phosphatase regulatory subunit Gene

中文名称：丙酮酸脱氢酶磷酸酶调节亚基

种属: Homo sapiens

同用名: PDP3

关于 PDPR

功能概要

丙酮酸脱氢酶复合物 (PDC) 催化丙酮酸的氧化脱羧作用，并将糖酵解与三羧酸循环和脂肪酸合成联系起来。 PDC 的去磷酸化和再激活由丙酮酸脱氢酶磷酸酶 (PDP) 催化。二聚体 PDP 具有催化亚基和调节亚基。该基因编码含有 FAD 的 PDP 调节亚基。编码的蛋白质用于降低 PDP 催化亚基对镁离子的敏感性。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2017 年 1 月]

Pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate and links glycolysis to the tricarboxylic acid cycle and fatty acid synthesis. The dephosphorylation and reactivation of PDC is catalyzed by pyruvate dehydrogenase Phosphatase (PDP). The dimeric PDP has a catalytic subunit and a regulatory subunit. This gene encodes the FAD-containing regulatory subunit of PDP. The encoded protein acts to decrease the sensitivity of the PDP catalytic subunit to magnesium ions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]