2. Gene
  3. DDX60 - DExD/H-box helicase 60 Gene

DDX60 - DExD/H-box helicase 60 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DExD/H-box 解旋酶 60

种属: Homo sapiens

基因 ID: 55601 | 基因类型: protein coding

关于 DDX60

Cytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:168,216,294-168,325,979 (from NCBI)

This gene has 12 transcripts (splice variants), 114 orthologues and 8 paralogues. Ubiquitous expression in stomach (RPKM 14.0), colon (RPKM 7.7) and 24 other tissues.

功能概要

以保守基序 Asp-Glu-Ala-Asp (DEAD) 为特征的 DEAD 盒蛋白是推定的 RNA 解旋酶，涉及许多涉及 RNA 结合和 RNA 二级结构改变的细胞过程。该基因编码一种 DEXD/H 盒 RNA 解旋酶，其作为抗病毒因子发挥作用并促进 RIG-I 样受体介导的信号传导。[RefSeq 提供，2017 年 4 月]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular procsses involving RNA binding and alteration of RNA secondary structure. This gene encodes a DEXD/H box RNA helicase that functions as an Antiviral factor and promotes RIG-I-like receptor-mediated signaling. [provided by RefSeq, Apr 2017]

DDX60 基因产物(2)

mRNA Protein Name
NM_001410861.1 NP_001397790.1 probable ATP-dependent RNA helicase DDX60 isoform 2
NM_017631.6 NP_060101.3 probable ATP-dependent RNA helicase DDX60 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables double-stranded DNA binding IDA
IDA: 通过直接分析推断
21791617 GOA
enables double-stranded RNA binding IDA
IDA: 通过直接分析推断
21791617 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21791617 GOA
enables single-stranded RNA binding IDA
IDA: 通过直接分析推断
21791617 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of MDA-5 signaling pathway IMP
IMP: 通过突变表型推断
21791617 GOA
involved in positive regulation of RIG-I signaling pathway IMP
IMP: 通过突变表型推断
21791617 GOA
involved in response to virus IDA
IDA: 通过直接分析推断
21791617 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
21791617 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DDX60 蛋白结构

DEAD

DEAD: DEAD/DEAH box helicase (768 - 924)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (1261 - 1330)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1712 a.a.
蛋白主名 其他名称

probable ATP-dependent RNA helicase DDX60

ATP-dependent RNA helicase DDX60

DDX60 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DDX60 Q8IY21 EIF3E Homo sapiens P60228
Pull Down
30833792
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Plantar Wart

Verruca Plantaris

Verrucae On Sole Of Foot

Mosaic Plantar Warts
Lip Cancer

Malignant Neoplasm Of Lip

Malignant Neoplasm Of Oral Aspect Of Lip, Not Specified Whether Upper Or Lower

Malignant Tumour Of Lip

Lip Neoplasms

Malignant Neoplasm Of Commissure Of Lip

Malignant Neoplasm Of External Lip, Not Specified As Upper Or Lower

Malignant Neoplasm Of Labial Commissure Of Lip

Malignant Neoplasm Of Lip, External

Malignant Neoplasm Of Lip, Inner Aspect

Malignant Neoplasm Of Lip, Vermilion Border

Malignant Neoplasm Of Lower Lip, Buccal Aspect

Malignant Neoplasm Of Lower Lip, Inner Aspect

Malignant Neoplasm Of Lower Lip, Mucosa

Malignant Neoplasm Of Lower Lip, Oral Aspect

Malignant Neoplasm Of Other Sites Of Lip

Malignant Neoplasm Of Vermilion Border Of Lip

Malignant Tumor Of Commissure Of Lip

Malignant Tumor Of Labial Mucosa

Malignant Tumor Of Lip

Malignant Tumor Of Lower Labial Mucosa

Malignant Tumor Of The Lip

Malignant Tumour Of Labial Commissure

Cancer Of Lip

Primary Malignant Neoplasm Of Vermilion Border Of Upper Lip

Upper Lip Cancer

Lower Lip Cancer

Primary Malignant Neoplasm Of Vermilion Border Of Lower Lip

Primary Malignant Neoplasm Of Vermilion Border Of Lip

Malignant Neoplasm Of Lipstick Area Of Upper Lip

Malignant Neoplasm Of Upper Lip Nos

Malignant Neoplasm Of Vermilion Border Of Upper Lip

Malignant Neoplasm Of Lipstick Area Of Lower Lip

Malignant Neoplasm Of Lower Lip Nos

Malignant Neoplasm Of Vermilion Border Of Lower Lip

Malignant Neoplasm Of Vermilion Border Nos

Malignant Neoplasm Of Buccal Aspect Of Upper Lip

Malignant Neoplasm Of Frenulum Of Upper Lip

Malignant Neoplasm Of Mucosa Of Upper Lip

Malignant Neoplasm Of Oral Aspect Of Upper Lip

Malignant Neoplasm Of Buccal Aspect Of Lower Lip

Malignant Neoplasm Of Frenulum Of Lower Lip

Malignant Neoplasm Of Mucosa Of Lower Lip

Malignant Neoplasm Of Oral Aspect Of Lower Lip

Malignant Neoplasm Of Buccal Aspect Of Lip, Not Specified Whether Upper Or Lower

Malignant Neoplasm Of Frenulum Of Lip, Not Specified Whether Upper Or Lower

Malignant Neoplasm Of Mucosa Of Lip, Not Specified Whether Upper Or Lower

Primary Malignant Neoplasm Of Commissure Of Lip

Primary Malignant Neoplasm Of Lip

Malignant Neoplasm Of Lip, Unspecified
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03664 DDX60 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS03665 DDX60L Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21550 Ddx60 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28068 Ddx60 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta DDX60 VGNC VGNC:71711
Mus musculus DDX60 MGD MGI:2384570
Rattus norvegicus DDX60 RGD RGD:1560014
Canis familiaris DDX60 VGNC VGNC:54938
Felis catus DDX60 VGNC VGNC:61421
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