2. Gene
  3. Foxo3 - forkhead box O3 Gene

Foxo3 - forkhead box O3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Fkhr2; FKHRL1; Foxo3a; 1110048B16Rik; 2010203A17Rik

基因 ID: 56484 | 基因类型: protein coding

关于 Foxo3

功能概要

Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial transcription; positive regulation of muscle atrophy; and positive regulation of pri-miRNA transcription by RNA polymerase II. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; female gonad development; and neuronal stem cell population maintenance. Located in cytosol; mitochondrial outer membrane; and nucleus. Part of protein-containing complex. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system. Used to study dermoid cyst of ovary. Orthologous to human FOXO3 (forkhead box O3). [provided by Alliance of Genome Resources, Apr 2022]

Foxo3 基因产物(2)

mRNA Protein Name
NM_001376967.1 NP_001363896.1 forkhead box protein O3
NM_019740.3 NP_062714.1 forkhead box protein O3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
14966295 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
19933931 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
14966295 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IGI
IGI: 通过遗传相互作用推断
19896444 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
17521387 MGI
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
17521387 MGI
enables mitochondrial transcription factor activity IMP
IMP: 通过突变表型推断
23283301 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17521387 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11353388 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
19933931 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response, signal transduction by p53 class mediator IDA
IDA: 通过直接分析推断
15383658 MGI
acts upstream of or within antral ovarian follicle growth IMP
IMP: 通过突变表型推断
14978268 MGI
acts upstream of or within brain morphogenesis IGI
IGI: 通过遗传相互作用推断
24483844 MGI
acts upstream of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
19896444 MGI
involved in cellular response to oxidative stress IDA
IDA: 通过直接分析推断
17521387 MGI
acts upstream of or within cellular response to oxidative stress IGI
IGI: 通过遗传相互作用推断
24483844 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IGI
IGI: 通过遗传相互作用推断
12431371 MGI
acts upstream of or within glucose homeostasis IMP
IMP: 通过突变表型推断
12855809 MGI
acts upstream of or within initiation of primordial ovarian follicle growth IMP
IMP: 通过突变表型推断
12855809 MGI
involved in mitochondrial transcription IMP
IMP: 通过突变表型推断
23283301 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
19896444 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21621563 MGI
acts upstream of or within neuronal stem cell population maintenance IGI
IGI: 通过遗传相互作用推断
19896444 MGI
acts upstream of or within oocyte maturation IMP
IMP: 通过突变表型推断
12855809 MGI
acts upstream of or within ovulation from ovarian follicle IMP
IMP: 通过突变表型推断
12855809 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12048180 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18054315 MGI
involved in positive regulation of autophagy IDA
IDA: 通过直接分析推断
18054315 MGI
involved in positive regulation of miRNA transcription IMP
IMP: 通过突变表型推断
19933931 MGI
involved in positive regulation of muscle atrophy IDA
IDA: 通过直接分析推断
18054315 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12930811 MGI
acts upstream of or within regulation of neural precursor cell proliferation IGI
IGI: 通过遗传相互作用推断
19896444 MGI
acts upstream of or within regulation of reactive oxygen species metabolic process IGI
IGI: 通过遗传相互作用推断
19896444 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17521387 MGI
involved in response to fatty acid IDA
IDA: 通过直接分析推断
32103177 MGI
involved in response to starvation IDA
IDA: 通过直接分析推断
18054315 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12857750 MGI
located in cytosol IDA
IDA: 通过直接分析推断
18054315 MGI
located in membrane IDA
IDA: 通过直接分析推断
15383658 MGI
colocalizes with mitochondrial matrix IDA
IDA: 通过直接分析推断
29445193 MGI
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
29445193 MGI
colocalizes with mitochondrion IDA
IDA: 通过直接分析推断
23283301 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12857750 MGI
part of protein-containing complex IDA
IDA: 通过直接分析推断
23283301 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

forkhead box protein O3

forkhead box O3a

forkhead protein FKHR2

Foxo3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Foxo3 Q9WVH4 SETD7 Homo sapiens Q8WTS6
Methyltransferase Ass
22402663
种属间
Foxo3 Q9WVH4 SETD7 Homo sapiens Q8WTS6
Anti Tag CoIP
22402663
种属内
Foxo3 Q9WVH4 Fcor Mus musculus P0DJI6
Anti Tag CoIP
22510882
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-154919 DC-Y13-27 Activator 99.52% 否
HY-176902 NSC126188 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Foxo3 NCBI NCBI:2309
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