2. Gene
  3. DUSP22 - dual specificity phosphatase 22 Gene

DUSP22 - dual specificity phosphatase 22 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：双特异性磷酸酶 22

种属: Homo sapiens

同用名: VHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2

基因 ID: 56940 | 基因类型: protein coding

关于 DUSP22

Cytogenetic location: 6p25.3 Genomic coordinates (GRCh38): 6:292,487-351,355 (from NCBI)

This gene has 16 transcripts (splice variants), 244 orthologues and 30 paralogues. Ubiquitous expression in testis (RPKM 10.7), spleen (RPKM 5.4) and 25 other tissues.

功能概要

启用非跨膜蛋白酪氨酸磷酸酶活性和蛋白酪氨酸激酶结合活性。参与多个过程，包括细胞对表皮生长因子刺激的反应；粘着斑组装的负调控；和非跨膜蛋白酪氨酸激酶活性的负调节。在 RNA 聚合酶 II 的转录负调节上游或负调节内起作用。位于质膜。部分细胞质；丝状肌动蛋白；和 lamellipodium 的前缘。 [由基因组资源联盟提供，2022 年 4 月]

Enables non-membrane spanning protein tyrosine Phosphatase activity and protein tyrosine kinase binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; negative regulation of focal adhesion assembly; and negative regulation of non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in plasma membrane. Part of cytoplasm; filamentous actin; and leading edge of lamellipodium. [provided by Alliance of Genome Resources, Apr 2022]

DUSP22 基因产物(2)

mRNA Protein Name
NM_001286555.3 NP_001273484.1 dual specificity protein phosphatase 22 isoform a
NM_020185.6 NP_064570.1 dual specificity protein phosphatase 22 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables non-membrane spanning protein tyrosine phosphatase activity IDA
IDA: 通过直接分析推断
20018849 GOA
enables protein tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
24714587 GOA
enables protein tyrosine phosphatase activity IDA
IDA: 通过直接分析推断
24714587 GOA
enables protein tyrosine/serine/threonine phosphatase activity IDA
IDA: 通过直接分析推断
38225265 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to epidermal growth factor stimulus IDA
IDA: 通过直接分析推断
20018849 GOA
involved in negative regulation of T cell receptor signaling pathway IDA
IDA: 通过直接分析推断
38225265 GOA
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
20018849 GOA
involved in negative regulation of focal adhesion assembly IDA
IDA: 通过直接分析推断
20018849 GOA
involved in negative regulation of non-membrane spanning protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
20018849 GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16636663 GOA
involved in peptidyl-tyrosine dephosphorylation IDA
IDA: 通过直接分析推断
20018849 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
20018849 GOA
part of filamentous actin IDA
IDA: 通过直接分析推断
20018849 GOA
located in leading edge of lamellipodium IDA
IDA: 通过直接分析推断
20018849 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
24714587 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DUSP22 蛋白结构

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (12 - 140)

  • 0
  • 100
  • 184 a.a.
蛋白主名 其他名称

dual specificity protein phosphatase 22

JNK-stimulating phosphatase 1

关联疾病

疾病名称 别名
Breast Implant-Associated Anaplastic Large Cell Lymphoma
Variola Major

Smallpox
Systemic Epstein-Barr Virus Positive T-Cell Lymphoma Of Childhood

Ebv-Positive T-Cell Lymphoproliferative Disorder Of Childhood

Systemic Epstein-Barr Virus-Positive T-Cell Lymphoma Of Childhood

Systemic Ebv-Positive T-Cell Lymphoma Of Childhood

Systemic Ebv+ T-Cell Lymphoma Of Childhood
Hepatosplenic T-Cell Lymphoma

Doid:0081049
Angioimmunoblastic T-Cell Lymphoma

Immunoblastic Lymphadenopathy

Lymphogranulomatosis X

T-Cell Lymphoma, Aild Type

Aitl

Ailt

Angioimmunoblastic Lymphadenopathy

Aild - [Angioimmunoblastic Lymphadenopathy With Dysproteinaemia]

Angioimmunoblastic Lymphoma
Mature T-Cell And Nk-Cell Lymphoma

Mature T-Cell And Natural Killer Cell Lymphoma

Nk-T Cell Lymphoma
Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome

Duane'S Syndrome

Duane Syndrome

Isolated Duane Retraction Syndrome

Co-Contractive Retraction Syndrome

Duane Anomaly, Isolated

Ocular Retraction Syndrome

Drs

Durs
Sezary'S Disease

Sezary Syndrome

Sézary Syndrome

Sezary'S Lymphoma

Sezary Disease

Sezary Erythroderma

Sezary Lymphoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-123846 MLS-0437605 Inhibitor 99.27% 否
HY-133095 BML-260 Activator 99.65% 否
HY-RS04061 DUSP22 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DUSP22 RGD RGD:1307146
Mus musculus DUSP22 MGD MGI:1915926
Canis familiaris DUSP22 VGNC VGNC:40133
Macaca mulatta DUSP22 VGNC VGNC:71844
Bos taurus DUSP22 VGNC VGNC:28256
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