2. Gene
  3. RALGAPB - Ral GTPase activating protein non-catalytic subunit beta Gene

RALGAPB - Ral GTPase activating protein non-catalytic subunit beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Ral GTP 酶激活蛋白非催化亚基β

种属: Homo sapiens

同用名: KIAA1219; RalGAPbeta

基因 ID: 57148 | 基因类型: protein coding

关于 RALGAPB

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,472,843-38,578,858 (from NCBI)

This gene has 9 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in thyroid (RPKM 11.6), testis (RPKM 11.5) and 25 other tissues.

功能概要

启用蛋白质异二聚化活性。预测参与 GTPase 活性的激活。预计作用于 Ral 蛋白信号转导的上游或内部；外囊定位的调节；和蛋白质定位的调节。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein heterodimerization activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within Ral protein signal transduction; regulation of exocyst localization; and regulation of protein localization. [provided by Alliance of Genome Resources, Apr 2022]

RALGAPB 基因产物(3)

mRNA Protein Name
NM_001282917.2 NP_001269846.1 ral GTPase-activating protein subunit beta isoform 1
NM_001282918.2 NP_001269847.1 ral GTPase-activating protein subunit beta isoform 2
NM_020336.4 NP_065069.1 ral GTPase-activating protein subunit beta isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
19520869 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ral GTPase-activating protein subunit beta

Ral GTPase activating protein non-catalytic beta subunit

RALGAPB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RALGAPB Q86X10 GOPC Homo sapiens Q9HD26-2
Y2H Prey Pooling
32296183
种属内
RALGAPB Q86X10 GOPC Homo sapiens Q9HD26-2
Validated Y2H
32296183
种属内
RALGAPB Q86X10 GOPC Homo sapiens Q9HD26-2
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Tubulinopathy

Tubulinopathies
Septooptic Dysplasia

Septo-Optic Dysplasia

De Morsier Syndrome

Growth Hormone Deficiency With Pituitary Anomalies

SOD

Pituitary Hormone Deficiency, Combined, 5

Septo-Optic Dysplasia Spectrum

Septo-Optic Dysplasia With Growth Hormone Deficiency

Pituitary Hormone Deficiency, Combined 5

Hypopituitarism And Septooptic 'Dysplasia'

GHDPA

CPHD5

Dysplasia, Septo-Optic

Kallmann Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11632 RALGAPB Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RALGAPB MGD MGI:2444531
Felis catus RALGAPB VGNC VGNC:64484
Canis familiaris RALGAPB VGNC VGNC:45334
Bos taurus RALGAPB VGNC VGNC:33703
Rattus norvegicus RALGAPB RGD RGD:1306861
Macaca mulatta RALGAPB VGNC VGNC:76562
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